Synthetic peptide containing a sequence corresponding to a region within amino acids 299-362 (IIGRQGAKIN EIRQMSGAQI KIANPVEGST DRQVTITGSA ASISLAQYLI NVRLSSETGG MGSS) of Human PCBP2/hnRNP E2 (NP_114366).
功能Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation.
组织特异性Detected in all tissues examined.
序列相似性Contains 3 KH domains.
翻译后修饰Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity.
细胞定位Nucleus. Cytoplasm. Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.