Anti-PCBP2/hnRNP E2抗体[376CT13.1.2] (ab61334)

概述

  • 产品名称Anti-PCBP2/hnRNP E2抗体[376CT13.1.2]
    参阅全部 PCBP2/hnRNP E2 一抗
  • 描述
    小鼠单克隆抗体[376CT13.1.2] to PCBP2/hnRNP E2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length human PCBP2 protein.

  • 阳性对照
    • This antibody gave a positive signal in the following whole cell lysates: K562; HeLa; HepG2; Raji.

性能

应用

Our Abpromise guarantee covers the use of ab61334 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 5 µg/ml. Detects a band of approximately 39 kDa (predicted molecular weight: 39 kDa). Abcam reccomends blocking with 3% milk.

靶标

  • 功能Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation.
  • 组织特异性Detected in all tissues examined.
  • 序列相似性Contains 3 KH domains.
  • 翻译后修饰Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity.
  • 细胞定位Nucleus. Cytoplasm. Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Alpha CP2 antibody
    • Alpha-CP2 antibody
    • alphaCP-2 antibody
    • Cbp antibody
    • CTBP antibody
    • Heterogeneous nuclear ribonucleoprotein E2 antibody
    • Heterogenous nuclear ribonucleoprotein E2 antibody
    • hnRNP E2 antibody
    • hnRNP-E2 antibody
    • HNRNPE2 antibody
    • Hnrnpx antibody
    • HNRPE2 antibody
    • Hnrpx antibody
    • MGC110998 antibody
    • PCBP2 antibody
    • PCBP2_HUMAN antibody
    • poly(rC) binding protein 2 antibody
    • Poly(rC)-binding protein 2 antibody
    • Putative heterogeneous nuclear ribonucleoprotein X antibody
    • rCbinding protein 2 antibody
    see all

Anti-PCBP2/hnRNP E2 antibody [376CT13.1.2] 图像

  • All lanes : Anti-PCBP2/hnRNP E2 antibody [376CT13.1.2] (ab61334) at 5 µg/ml

    Lane 1 : K562 (Human erythromyeloblastoid leukemia cell line) Whole Cell Lysate
    Lane 2 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate
    Lane 3 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate
    Lane 4 : Raji (Human Burkitt's lymphoma cell line) Whole Cell Lysate

    Lysates/proteins at 20 µg per lane.

    Secondary
    Goat Anti-Mouse IgG H&L (HRP) preadsorbed (ab97040) at 1/5000 dilution

    Performed under reducing conditions.

    Predicted band size : 39 kDa
    Observed band size : 39 kDa
    Additional bands at : 110 kDa,37 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 3 minutes

Anti-PCBP2/hnRNP E2 antibody [376CT13.1.2] (ab61334)参考文献

ab61334 has not yet been referenced specifically in any publications.

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