Anti-PCB抗体(ab115579)

概述

• 产品名称Anti-PCB抗体
  参阅全部 PCB 一抗
• 描述
  山羊多克隆抗体to PCB
• 经测试应用适用于: WB, ELISA, IHC-Pmore details
• 种属反应性
  与反应: Mouse, Human
  预测可用于: Rat, Cow, Dog, Pig
• 免疫原

  Synthetic peptide:

  KFKEVKKAYVEANQ

  with a Cysteine residue linker, corresponding to internal sequence amino acids 886-899 of Human PCB (NP_000911.2).
  Run BLAST with Run BLAST with
• 阳性对照
  • Human liver tissue; Mouse liver lysate.

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
• 存储溶液pH: 7.30
  Preservative: 0.02% Sodium azide
  Constituents: 99% Tris buffered saline, 0.5% BSA
• Concentration information loading...
• 纯度Protein G purified
• 克隆多克隆
• 同种型IgG
• 研究领域
  • Signal Transduction
  • Metabolism
  • Energy Metabolism

  • Signal Transduction
  • Metabolism
  • Lipid metabolism

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Metabolism of carbohydrates

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Carbohydrate metabolism

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Energy Metabolism

  • Metabolism
  • Types of disease
  • Cancer

相关产品

• Compatible Secondaries
  • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
  • Donkey Anti-Goat IgG H&L (HRP) (ab205723)
• Positive Controls
  • Mouse liver tissue lysate - mitochondrial extract (ab110343)
  • Mouse liver tissue lysate - mitochondrial extract (ab110349)

应用

靶标

• 功能Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
• 通路Carbohydrate biosynthesis; gluconeogenesis.
• 疾病相关Defects in PC are the cause of pyruvate carboxylase deficiency (PC deficiency) [MIM:266150]. PC deficiency leads to lactic acidosis, mental retardation and death. It occurs in three forms: mild or type A, severe neonatal or type B, and a very mild lacticacidemia.
• 序列相似性Contains 1 ATP-grasp domain.
  Contains 1 biotin carboxylation domain.
  Contains 1 biotinyl-binding domain.
  Contains 1 carboxyltransferase domain.
• 细胞定位Mitochondrion matrix.

• Target information above from: UniProt accession P11498 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 338471 Cow
  • Entrez Gene: 5091 Human
  • Entrez Gene: 18563 Mouse
  • Entrez Gene: 25104 Rat
  • Omim: 608786 Human
  • SwissProt: Q29RK2 Cow
  • SwissProt: P11498 Human
  • SwissProt: Q05920 Mouse

  • SwissProt: P52873 Rat
  • Unigene: 89890 Human
  • Unigene: 1845 Mouse
  • Unigene: 11094 Rat

  see all
• 别名
  • mitochondrial antibody
  • OTTHUMP00000235155 antibody
  • OTTHUMP00000235156 antibody

  • PC antibody
  • PCB antibody
  • Pcx antibody
  • PYC_HUMAN antibody
  • Pyruvate carboxylase antibody
  • Pyruvate carboxylase mitochondrial antibody
  • Pyruvic carboxylase antibody

  see all