概述

描述

  • 性质Synthetic

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技术指标

Our Abpromise guarantee covers the use of ab5011 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • 补充说明


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse PC1, catalog ab3532. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • BDP
    • NEC 1
    • NEC1
    • NEC1_HUMAN
    • Neuroendocrine convertase 1
    • PC1
    • PC3
    • PCSK1
    • Prohormone convertase 1
    • Prohormone convertase 1/3
    • Prohormone convertase 3
    • Proprotein convertase 1
    • SPC3
    see all
  • 功能Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.
  • 疾病相关Defects in PCSK1 are the cause of proprotein convertase 1 deficiency (PC1 deficiency) [MIM:600955]. PC1 deficiency is characterized by obesity, hypogonadism, hypoadrenalism, reactive hypoglycemia as well as marked small-intestinal absorptive dysfunction It is due to impaired processing of prohormones.
  • 序列相似性Belongs to the peptidase S8 family. Furin subfamily.
  • 细胞定位Cytoplasmic vesicle > secretory vesicle. Localized in the secretion granules.
  • Information by UniProt

PC1/3 peptide (ab5011)参考文献

This product has been referenced in:
  • Helwig M  et al. PC1/3 and PC2 gene expression and post-translational endoproteolytic pro-opiomelanocortin processing is regulated by photoperiod in the seasonal Siberian hamster (Phodopus sungorus). J Neuroendocrinol 18:413-25 (2006). Read more (PubMed: 16684131) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"