概述

  • 产品名称Anti-PBX1抗体
    参阅全部 PBX1 一抗
  • 描述
    山羊多克隆抗体to PBX1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Chicken, Monkey, Zebrafish
  • 免疫原

    Synthetic peptide (

    C-ATNVSAHGSQANSPS

    ) corresponding to internal sequence amino acids 313-327 of Human PBX1 (NP_002576.1).

  • 阳性对照
    • Lysates of cell line K562

性能

应用

Our Abpromise guarantee covers the use of ab104247 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 - 1.5 µg/ml. Predicted molecular weight: 47 kDa.

靶标

  • 功能Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation.
  • 组织特异性Expressed in all tissues except in cells of the B and T lineage.
  • 疾病相关Note=A chromosomal aberration involving PBX1 is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with TCF3. E2A-PBX1 transforms cells by constitutively activating transcription of genes regulated by PBX1 or by other members of the PBX protein family.
  • 序列相似性Belongs to the TALE/PBX homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DKFZp686B09108 antibody
    • Homeo box protein PBX1 antibody
    • Homeo box protein PRL antibody
    • Homeobox protein PBX 1 antibody
    • Homeobox protein PBX1 antibody
    • Homeobox protein PRL antibody
    • MGC126627 antibody
    • PBX 1 antibody
    • Pbx1 antibody
    • PBX1_HUMAN antibody
    • Pre B cell leukemia homeobox 1 antibody
    • Pre B cell leukemia transcription factor 1 antibody
    • Pre-B-cell leukemia transcription factor 1 antibody
    • PRL antibody
    see all

Anti-PBX1 antibody 图像

Anti-PBX1 antibody (ab104247)参考文献

ab104247 has not yet been referenced specifically in any publications.

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