Anti-PBX1抗体[146C1a] (ab66496)

概述

  • 产品名称Anti-PBX1抗体[146C1a]
    参阅全部 PBX1 一抗
  • 描述
    小鼠单克隆抗体[146C1a] to PBX1
  • 经测试应用适用于: WB, Dot blotmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment from the internal region of human PBX1

性能

应用

Our Abpromise guarantee covers the use of ab66496 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 47 kDa.
Dot blot Use at an assay dependent dilution.

靶标

  • 功能Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation.
  • 组织特异性Expressed in all tissues except in cells of the B and T lineage.
  • 疾病相关Note=A chromosomal aberration involving PBX1 is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with TCF3. E2A-PBX1 transforms cells by constitutively activating transcription of genes regulated by PBX1 or by other members of the PBX protein family.
  • 序列相似性Belongs to the TALE/PBX homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DKFZp686B09108 antibody
    • Homeo box protein PBX1 antibody
    • Homeo box protein PRL antibody
    • Homeobox protein PBX 1 antibody
    • Homeobox protein PBX1 antibody
    • Homeobox protein PRL antibody
    • MGC126627 antibody
    • PBX 1 antibody
    • Pbx1 antibody
    • PBX1_HUMAN antibody
    • Pre B cell leukemia homeobox 1 antibody
    • Pre B cell leukemia transcription factor 1 antibody
    • Pre-B-cell leukemia transcription factor 1 antibody
    • PRL antibody
    see all

Anti-PBX1 antibody [146C1a] 图像

Anti-PBX1 antibody [146C1a] (ab66496)参考文献

ab66496 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your email last week and for your patience. I have heard back from the testing laboratory, and unfortunately the antibody has not been specifically tested against the isoform B. However, we do have a PBX1 antibody that I would expect to r...

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