RabMAb

Anti-PAX8抗体[ZR-1] (ab122944)

概述

  • 产品名称Anti-PAX8抗体[ZR-1]
    参阅全部 PAX8 一抗
  • 描述
    兔单克隆抗体[ZR-1] to PAX8
  • 经测试应用适用于: IHC-P, IHC-Frmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to the C-terminus of Human PAX8.

  • 阳性对照
    • Thyroid carcinoma, Ovarian Clear Cell Carcinoma.

性能

应用

Our Abpromise guarantee covers the use of ab122944 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
IHC-Fr 1/50 - 1/100.

靶标

  • 功能Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
  • 组织特异性Expressed in the excretory system, thyroid gland and Wilms tumors.
  • 疾病相关Defects in PAX8 are the cause of congenital hypothyroidism non-goitrous type 2 (CHNG2) [MIM:218700]. CHNG2 is a disease characterized by thyroid dysgenesis, the most frequent cause of congenital hypothyroidism, accounting for 85% of case. The thyroid gland can be completely absent (athyreosis), ectopically located and/or severely hypoplastic. Ectopic thyroid gland is the most frequent malformation, with thyroid tissue being found most often at the base of the tongue.
  • 序列相似性Contains 1 paired domain.
  • 发展阶段In developing excretory system, during thyroid differentiation and in adult thyroid.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • OTTHUMP00000158659 antibody
    • OTTHUMP00000158660 antibody
    • OTTHUMP00000203723 antibody
    • OTTHUMP00000203724 antibody
    • Paired box 8 antibody
    • Paired box gene 8 antibody
    • paired box homeotic gene 8 antibody
    • Paired box protein Pax 8 antibody
    • Paired box protein Pax-8 antibody
    • Paired domain gene 8 antibody
    • PAX 8 antibody
    • PAX8 antibody
    • PAX8_HUMAN antibody
    see all

Anti-PAX8 antibody [ZR-1] (ab122944)参考文献

ab122944 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"