概述

  • 产品名称Anti-PAX8抗体
    参阅全部 PAX8 一抗
  • 描述
    小鼠单克隆抗体to PAX8
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length Human protein (AAH01060) with a proprietary tag.

  • 阳性对照
    • Liver tissue lysate; LNCap or Hs 181.Tes cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab89508 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 48 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 功能Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
  • 组织特异性Expressed in the excretory system, thyroid gland and Wilms tumors.
  • 疾病相关Defects in PAX8 are the cause of congenital hypothyroidism non-goitrous type 2 (CHNG2) [MIM:218700]. CHNG2 is a disease characterized by thyroid dysgenesis, the most frequent cause of congenital hypothyroidism, accounting for 85% of case. The thyroid gland can be completely absent (athyreosis), ectopically located and/or severely hypoplastic. Ectopic thyroid gland is the most frequent malformation, with thyroid tissue being found most often at the base of the tongue.
  • 序列相似性Contains 1 paired domain.
  • 发展阶段In developing excretory system, during thyroid differentiation and in adult thyroid.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • OTTHUMP00000158659 antibody
    • OTTHUMP00000158660 antibody
    • OTTHUMP00000203723 antibody
    • OTTHUMP00000203724 antibody
    • Paired box 8 antibody
    • Paired box gene 8 antibody
    • paired box homeotic gene 8 antibody
    • Paired box protein Pax 8 antibody
    • Paired box protein Pax-8 antibody
    • Paired domain gene 8 antibody
    • PAX 8 antibody
    • PAX8 antibody
    • PAX8_HUMAN antibody
    see all

Anti-PAX8 antibody 图像

  • Anti-PAX8 antibody (ab89508) at 5 µg/ml + Human liver lysate at 50 µg

    Predicted band size : 48 kDa
  • Anti-PAX8 antibody (ab89508) at 5 µg/ml + LNCaP cell lysate at 50 µg

    Predicted band size : 48 kDa
  • Anti-PAX8 antibody (ab89508) at 5 µg/ml + Hs 181.Tes cell lysate at 50 µg

    Predicted band size : 48 kDa
  • Anti-PAX8 antibody (ab89508) at 5 µg/ml + immunogen (full length recombinant protein with a tag of 26kDa) at 0.2 µg

    Predicted band size : 48 kDa
    Observed band size : 75 kDa (why is the actual band size different from the predicted?)

Anti-PAX8 antibody (ab89508)参考文献

ab89508 has not yet been referenced specifically in any publications.

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