概述

  • 产品名称Anti-PAX8抗体
    参阅全部 PAX8 一抗
  • 描述
    兔多克隆抗体to PAX8
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    3 synthetic peptides (human) conjugated to KLH

  • 阳性对照
    • Induced culture of E.coli (one shot Top10 competent cells).

性能

应用

Our Abpromise guarantee covers the use of ab82845 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明ELISA: Use at an assay dependent dilution.
    Antibody specificity was verified by direct ELISA against the 3 immunogen peptides. A minimum titer of 1/50000 is determined for one of the three peptides.
    WB: 1/1000. Detects a band of approximately 62 kDa (predicted molecular weight: 62 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
    • 组织特异性Expressed in the excretory system, thyroid gland and Wilms tumors.
    • 疾病相关Defects in PAX8 are the cause of congenital hypothyroidism non-goitrous type 2 (CHNG2) [MIM:218700]. CHNG2 is a disease characterized by thyroid dysgenesis, the most frequent cause of congenital hypothyroidism, accounting for 85% of case. The thyroid gland can be completely absent (athyreosis), ectopically located and/or severely hypoplastic. Ectopic thyroid gland is the most frequent malformation, with thyroid tissue being found most often at the base of the tongue.
    • 序列相似性Contains 1 paired domain.
    • 发展阶段In developing excretory system, during thyroid differentiation and in adult thyroid.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • OTTHUMP00000158659 antibody
      • OTTHUMP00000158660 antibody
      • OTTHUMP00000203723 antibody
      • OTTHUMP00000203724 antibody
      • Paired box 8 antibody
      • Paired box gene 8 antibody
      • paired box homeotic gene 8 antibody
      • Paired box protein Pax 8 antibody
      • Paired box protein Pax-8 antibody
      • Paired domain gene 8 antibody
      • PAX 8 antibody
      • PAX8 antibody
      • PAX8_HUMAN antibody
      see all

    Anti-PAX8 antibody 图像

    • All lanes : Anti-PAX8 antibody (ab82845) at 1/1000 dilution

      Lane 1 : uninduced culture of E.coli (one shot Top10 competent cells)
      Lane 2 : induced culture of E.coli (one shot Top10 competent cells)

      Secondary
      anti-Rabbit IgG HRP at 1/1000 dilution

      Predicted band size : 62 kDa
      Observed band size : 62 kDa
      Additional bands at : 40 kDa,50 kDa. We are unsure as to the identity of these extra bands.

    Anti-PAX8 antibody (ab82845)参考文献

    ab82845 has not yet been referenced specifically in any publications.

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