Anti-PAX7抗体(ab86026)

概述

• 产品名称
  Anti-PAX7抗体
  参阅全部 PAX7 一抗
• 描述
  兔多克隆抗体to PAX7
• 经测试应用
  适用于: WBmore details
• 种属反应性
  与反应: Mouse, Human
  
• 免疫原

  Three synthetic peptides (Human) conjugated to KLH

• 阳性对照
  • An induced culture of E. coli

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• 存储溶液
  Preservative: 0.01% Thimerosal (merthiolate)
  Constituents: Whole serum
• 纯度
  Whole antiserum
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Epigenetics and Nuclear Signaling
  • Transcription
  • Domain Families
  • Developmental Families
  • PAX

  • Stem Cells
  • Lineage Markers
  • Ectoderm

  • Stem Cells
  • Mesenchymal Stem Cells
  • Myogenesis

  • Developmental Biology
  • Lineage specification
  • Ectoderm

  • Developmental Biology
  • Organogenesis
  • Skeletal development
  • Muscle

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

应用

靶标

• 功能
  Probable transcription factor. May have a role in myogenesis.
• 疾病相关
  Defects in PAX7 are a cause of rhabdomyosarcoma type 2 (RMS2) [MIM:268220]. It is a form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchimal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. Note=A chromosomal aberration involving PAX7 is found in rhabdomyosarcoma. Translocation t(1;13)(p36;q14) with FOXO1. The resulting protein is a transcriptional activator.
• 序列相似性
  Belongs to the paired homeobox family.
  Contains 1 homeobox DNA-binding domain.
  Contains 1 paired domain.
• 细胞定位
  Nucleus.

• Target information above from: UniProt accession P23759 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 5081 Human
  • Entrez Gene: 18509 Mouse
  • Omim: 167410 Human
  • SwissProt: P23759 Human
  • SwissProt: P47239 Mouse
  • Unigene: 113253 Human
  • Unigene: 218760 Mouse
• 别名
  • FLJ37460 antibody
  • HUP1 antibody
  • OTTHUMP00000002534 antibody

  • Paired box 7 antibody
  • Paired box gene 7 antibody
  • Paired box homeotic gene 7 antibody
  • Paired box protein Pax-7 antibody
  • Paired domain gene 7 antibody
  • Paired domain gene HuP1 antibody
  • Pax7 antibody
  • PAX7 transcriptional factor antibody
  • PAX7/FKHR fusion gene, included antibody
  • PAX7_HUMAN antibody
  • PAX7B antibody
  • RGD1564360 antibody
  • RMS2 antibody

  see all

实验方案

• Western blot protocols