Anti-PAX7抗体(ab110111)

概述

  • 产品名称
  • 描述
    山羊多克隆抗体to PAX7
  • 经测试应用
    适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Cow, Dog, Chimpanzee, Gorilla
  • 免疫原

    Synthetic peptide:

    CSQRADSIKPGDS

    , corresponding to internal sequence amino acids 423-435 of Human PAX7

  • 阳性对照
    • Human Tonsil tissue.

性能

应用

Our Abpromise guarantee covers the use of ab110111 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/2000.
IHC-P Use a concentration of 3 - 6 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能
    Probable transcription factor. May have a role in myogenesis.
  • 疾病相关
    Defects in PAX7 are a cause of rhabdomyosarcoma type 2 (RMS2) [MIM:268220]. It is a form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchimal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. Note=A chromosomal aberration involving PAX7 is found in rhabdomyosarcoma. Translocation t(1;13)(p36;q14) with FOXO1. The resulting protein is a transcriptional activator.
  • 序列相似性
    Belongs to the paired homeobox family.
    Contains 1 homeobox DNA-binding domain.
    Contains 1 paired domain.
  • 细胞定位
    Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ37460 antibody
    • HUP1 antibody
    • OTTHUMP00000002534 antibody
    • Paired box 7 antibody
    • Paired box gene 7 antibody
    • Paired box homeotic gene 7 antibody
    • Paired box protein Pax-7 antibody
    • Paired domain gene 7 antibody
    • Paired domain gene HuP1 antibody
    • Pax7 antibody
    • PAX7 transcriptional factor antibody
    • PAX7/FKHR fusion gene, included antibody
    • PAX7_HUMAN antibody
    • PAX7B antibody
    • RGD1564360 antibody
    • RMS2 antibody
    see all

图片

  • ab110111 at 6 µg/ml staining PAX7 in formalin-fixed, paraffin-embedded Human Tonsil followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

文献

ab110111 has not yet been referenced specifically in any publications.

客户评价及客户问答

Abcam has not validated the combination of species/application used in this Abreview.
Application
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample
Chicken Tissue sections (Chicken Embryo Muscle)
Antigen retrieval step
Heat mediated - Buffer/Enzyme Used: Citrate Buffer pH6,0
Permeabilization
No
Specification
Chicken Embryo Muscle
Fixative
Formaldehyde
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提交于 May 18 2017

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