概述

  • 产品名称Anti-PAX5抗体[1EW]
    参阅全部 PAX5 一抗
  • 描述
    小鼠单克隆抗体[1EW] to PAX5
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length native PAX5 (purified) (Human)

  • 阳性对照
    • Human acute lymphoblastic leukemia

性能

应用

Our Abpromise guarantee covers the use of ab67005 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/20 - 1/40.
    heat induced epitope retrieval for paraffin sections using 10mM citrate buffer (pH6.0) is recommended.

    Note: When utilized in immunohistochemistry, the use of H2O2 to block endogenous peroxidase has been shown to have a detrimental effect on the epitope recognised by ab67005. It is, therefore, CRITICAL that blocking with H2O2 should be carried out after application of the primary antibody with solutions of no greater than 3%. If these recommendations are not followed, staining intensity will be reduced.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.
    • 疾病相关A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with ZNF521. Translocation t(9;3)(p13;p14.1) with FOXP1. Translocation t(9;12)(p13;p13) with ETV6.
      Leukemia, acute lymphoblastic, 3
    • 序列相似性Contains 1 paired domain.
    • 发展阶段Expressed at early B-cell differentiation, in the developing CNS and in adult testis.
    • 翻译后修饰O-glycosylated.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • B cell lineage specific activator antibody
      • B cell lineage specific activator protein antibody
      • B cell specific activator protein antibody
      • B cell specific transcription factor antibody
      • B-cell-specific transcription factor antibody
      • BSAP antibody
      • EBB-1 antibody
      • KLP antibody
      • Paired box 5 antibody
      • Paired box gene 5 (B cell lineage specific activator protein) antibody
      • Paired box gene 5 (B cell lineage specific activator) antibody
      • Paired box gene 5 antibody
      • Paired box homeotic gene 5 antibody
      • Paired box protein Pax 5 antibody
      • Paired box protein Pax-5 antibody
      • Paired domain gene 5 antibody
      • PAX 5 antibody
      • PAX5 antibody
      • PAX5_HUMAN antibody
      • Transcription factor PAX 5 antibody
      see all

    Anti-PAX5 antibody [1EW] 图像

    • Human acute lymphoblastic leukemia: immunohistochemical staining for Pax5 with 1/20 ab67005. Note nuclear staining of B cells. Paraffin section.

    Anti-PAX5 antibody [1EW] (ab67005)参考文献

    ab67005 has not yet been referenced specifically in any publications.

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