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Apoptosis pathway card

Learn about pathways involved in apoptosis induction, caspase activation and phagocytosis of apoptotic cells.

This pathway card outlines: 

  • Intrinsic and extrinsic pathways of apoptosis induction
  • Caspase activation and the caspase cascade
  • Phagocyosis of apoptotic cells

Apoptosis, or programmed cell death, is important in development, aging and disease.

Apoptosis is triggered via extrinsic or intrinsic pathways; the extrinsic pathway involves ligand binding to death receptors, whereas the intrinsic pathway activates in response to DNA damage, ischemia or oxidative stress.

Activity of the intrinsic or extrinsic pathway leads to caspase activation. Caspases then cleave cytoskeletal proteins and nuclear lamins, and promote DNA degradation. Finally, apoptotic cells undergo phagocytosis.

Download the Apoptosis pathway card.

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