概述

  • 产品名称Anti-PARP3抗体
    参阅全部 PARP3 一抗
  • 描述
    山羊多克隆抗体to PARP3
  • 经测试应用适用于: IHC-Pmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    YEDYNCTLNQTNIEN

    , corresponding to internal sequence amino acids 63-77 of Human PARP3 (NP_001003931.2; NP_001003935.2)

  • 阳性对照
    • Human kidney and liver tissue.

性能

应用

Our Abpromise guarantee covers the use of ab110154 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 3.75 µg/ml.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
    • 组织特异性Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.
    • 序列相似性Contains 1 PARP alpha-helical domain.
      Contains 1 PARP catalytic domain.
    • 结构域According to PubMed:10329013, the N-terminal domain (54 amino acids) of isoform 2 is responsible for its centrosomal localization. The C-terminal region contains the catalytic domain.
    • 翻译后修饰Auto-poly(ADP)-ribosylation.
    • 细胞定位Nucleus. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > centrosome > centriole. Core component of the centrosome. Preferentially localized to the daughter centriole throughout the cell cycle. According to PubMed:16924674, it is almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ADP ribosyltransferase (NAD+; poly (ADP ribose) antibody
      • ADP ribosyltransferase diphtheria toxin like 3 antibody
      • ADPRT-3 antibody
      • ADPRT3 antibody
      • ADPRTL2 antibody
      • ADPRTL3 antibody
      • ARTD3 antibody
      • hPARP 3 antibody
      • hPARP-3 antibody
      • hPARP3 antibody
      • IRT 1 antibody
      • IRT1 antibody
      • NAD(+) ADP ribosyltransferase 3 antibody
      • NAD(+) ADP-ribosyltransferase 3 antibody
      • NAD+ ADP ribosyltransferase 3 antibody
      • pADPRT 3 antibody
      • pADPRT-3 antibody
      • pADPRT3 antibody
      • PARP 3 antibody
      • PARP-3 antibody
      • PARP3 antibody
      • PARP3_HUMAN antibody
      • Poly (ADP ribose) polymerase family, member 3 antibody
      • Poly (ADP ribose) synthetase 3 antibody
      • Poly [ADP-ribose] polymerase 3 antibody
      • Poly[ADP ribose] synthetase 3 antibody
      • Poly[ADP-ribose] synthase 3 antibody
      see all

    Anti-PARP3 antibody 图像

    • Immunohistochemical analysis of Formalin-Fixed, Paraffin-Embedded Human Kidney using ab110154 at 3.75µg/ml.
    • Immunohistochemical analysis of Formalin-Fixed, Paraffin-Embedded Human Liver using ab110154 at 3.75µg/ml

    Anti-PARP3 antibody (ab110154)参考文献

    ab110154 has not yet been referenced specifically in any publications.

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