概述

  • 产品名称Anti-PARC抗体
    参阅全部 PARC 一抗
  • 描述
    兔多克隆抗体to PARC
  • 经测试应用适用于: ICC, WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    17 amino acid synthetic peptide, conjugated to KLH, from the C terminal region of Human PARC

  • 阳性对照
    • Human testis tissue

性能

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应用

Our Abpromise guarantee covers the use of ab115631 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC Use at an assay dependent concentration.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 281 kDa.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Cytoplasmic anchor protein in p53-associated protein complex. Regulates the subcellular localization of p53 and subsequent function. Seems to be part of an atypical cullin-RING-based E3 ubiquitin-protein ligase complex. In vitro, complexes of CUL9/PARC with either CUL7 or TP53 contain E3 ubiquitin-protein ligase activity.
  • 组织特异性Ubiquitously expressed in all tissues with highest expression in testis brain and kidney.
  • 序列相似性Belongs to the cullin family.
    Contains 1 DOC domain.
    Contains 1 IBR-type zinc finger.
    Contains 2 RING-type zinc fingers.
  • 结构域The IBR domain is required for interaction with UBCH7 and UBCH8.
  • 翻译后修饰In vitro, self-ubiquitination in the presence of E1, E2 and ubiquitin.
    Neddylated.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CUL-9 antibody
    • Cul9 antibody
    • CUL9_HUMAN antibody
    • Cullin-9 antibody
    • DKFZp686G1042 antibody
    • DKFZp686P2024 antibody
    • H7AP1 antibody
    • KIAA0708 antibody
    • OTTHUMP00000039816 antibody
    • p53 associated parkin like cytoplasmic protein antibody
    • p53-associated parkin-like cytoplasmic protein antibody
    • PARC antibody
    • parkin-like cytoplasmic p53 binding protein antibody
    • RP3 330M21.2 antibody
    • UbcH 7 associated protein 1 antibody
    • UbcH7 associated protein 1 antibody
    • UbcH7-associated protein 1 antibody
    see all

Anti-PARC antibody 图像

  • ab115631 at 5ug/ml staining PARC in Human testis tissue by immunohistochemistry (FFPE). Following primary incubation slides were incubated with biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-PARC antibody (ab115631)参考文献

ab115631 has not yet been referenced specifically in any publications.

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