Anti-Parathyroid Hormone抗体[D1.5] (ab14501)

概述

  • 产品名称Anti-Parathyroid Hormone抗体[D1.5]
    参阅全部 Parathyroid Hormone 一抗
  • 描述
    小鼠单克隆抗体[D1.5] to Parathyroid Hormone
  • 特异性Ab14501 reacts with parathyroid hormone peptides (aa 53-68; 53-84; 7-84; 1-84); affinity: > 2 x 1010 l/mol. There are no cross reactivities with synthetic parathyroid hormone peptides (aa 1-10; 1-34; 1-38).
  • 经测试应用适用于: ELISA, IHC-P, IHC-Frmore details
  • 种属反应性
    与反应: Human
    预测可用于: Cow, Dog, Cynomolgus Monkey
  • 免疫原

    bTG conjugated synthetic peptide:

    KKEDNVLVESHEKSLGEADKADVNVLTKAKSQ

    , corresponding to amino acids 53-84 of Human Parathyroid Hormone.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: None
    Constituents: 0.1M PBS, pH 7.4
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 克隆编号D1.5
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab14501 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent concentration. Use at a concentration of 500 ng/ml.
ILMA: Use at a concentration of 500 ng/ml.
IHC-P Use a concentration of 2 µg/ml.
IHC-Fr Use a concentration of 2 µg/ml.

靶标

  • 功能PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
  • 疾病相关Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:146200]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
  • 序列相似性Belongs to the parathyroid hormone family.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • hPTH antibody
    • Parathormone antibody
    • Parathyrin antibody
    • Parathyroid hormone 1 antibody
    • Parathyroid hormone antibody
    • PTH antibody
    • PTH1 antibody
    • PTH1 receptor antibody
    • PTH1R antibody
    • PTHR antibody
    • PTHR1 antibody
    • PTHY_HUMAN antibody
    see all

Anti-Parathyroid Hormone antibody [D1.5] (ab14501)参考文献

ab14501 has not yet been referenced specifically in any publications.

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