概述

  • 产品名称Anti-PAR6抗体
    参阅全部 PAR6 一抗
  • 描述
    山羊多克隆抗体to PAR6
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Peptide with sequence

    GSRIRGDGSGFSL

    , from C Terminus of the protein sequence according to NP_058644

  • 阳性对照
    • Human Brain and Pancreas extracts.
  • 常规说明GenBank Accession Number – NP_058644.

性能

应用

Our Abpromise guarantee covers the use of ab6022 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
IHC-P
  • 应用说明Peptide ELISA: Antibody detection limit dilution 1:8,000.
    IHC-P: Use at a concentration of 5 - 10 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
    • 组织特异性Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.
    • 序列相似性Belongs to the PAR6 family.
      Contains 1 OPR domain.
      Contains 1 PDZ (DHR) domain.
      Contains 1 pseudo-CRIB domain.
    • 结构域The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.
      The OPR domain mediates interactions with MAP2K5.
      The PDZ domain mediates the interaction with CRB3.
    • 细胞定位Cytoplasm. Cell membrane. Cell projection > ruffle. Cell junction > tight junction. Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 0710008C04Rik antibody
      • 2610010A15Rik antibody
      • Par 6 partitioning defective 6 C elegans homolog alpha antibody
      • Par 6 partitioning defective 6 homolog alpha antibody
      • Par 6 partitioning defective 6 homolog alpha C elegans antibody
      • PAR 6A antibody
      • PAR-6 alpha antibody
      • PAR-6 antibody
      • par-6 family cell polarity regulator alpha antibody
      • PAR-6A antibody
      • PAR6 antibody
      • PAR6A_HUMAN antibody
      • PAR6alpha antibody
      • PAR6C antibody
      • Pard6a antibody
      • Partitioning defective 6 homolog alpha antibody
      • partitioning-defective protein 6 antibody
      • partitioning-defective protein 6, C. elegans, homolog of, alpha antibody
      • Tax interacting protein 40 antibody
      • Tax interaction protein 40 antibody
      • TAX40 antibody
      • TIP 40 antibody
      • TIP-40 antibody
      • TIP40 antibody
      see all

    Anti-PAR6 antibody 图像

    • Ab6022 (10ug/ml) staining human PAR6 in human pancreas by immunohistochemistry using paraffin embedded tissue. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining.

      Ab6022 shows strong cytoplasmic staining in rare cells of intralobular ducts.

    • ab6022 at 5ug/ml staining PAR6 in human heart tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections). Tissue underwent antigen retrieval in steam with citrate buffer (pH 6.0). The AP-staining procedure was used for detection.

    Anti-PAR6 antibody (ab6022)参考文献

    This product has been referenced in:

    See 1 Publication for this product

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