Anti-PAR6抗体(ab111823)

概述

  • 产品名称Anti-PAR6抗体
    参阅全部 PAR6 一抗
  • 描述
    兔多克隆抗体to PAR6
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A peptide from the n-terminal and a peptide from the c-terminal region of PAR6 conjugated to KLH and co-immunized into rabbits

性能

应用

Our Abpromise guarantee covers the use of ab111823 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 37 kDa.
ICC/IF 1/100.

靶标

  • 功能Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
  • 组织特异性Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.
  • 序列相似性Belongs to the PAR6 family.
    Contains 1 OPR domain.
    Contains 1 PDZ (DHR) domain.
    Contains 1 pseudo-CRIB domain.
  • 结构域The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.
    The OPR domain mediates interactions with MAP2K5.
    The PDZ domain mediates the interaction with CRB3.
  • 细胞定位Cytoplasm. Cell membrane. Cell projection > ruffle. Cell junction > tight junction. Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 0710008C04Rik antibody
    • 2610010A15Rik antibody
    • Par 6 partitioning defective 6 C elegans homolog alpha antibody
    • Par 6 partitioning defective 6 homolog alpha antibody
    • Par 6 partitioning defective 6 homolog alpha C elegans antibody
    • PAR 6A antibody
    • PAR-6 alpha antibody
    • PAR-6 antibody
    • par-6 family cell polarity regulator alpha antibody
    • PAR-6A antibody
    • PAR6 antibody
    • PAR6A_HUMAN antibody
    • PAR6alpha antibody
    • PAR6C antibody
    • Pard6a antibody
    • Partitioning defective 6 homolog alpha antibody
    • partitioning-defective protein 6 antibody
    • partitioning-defective protein 6, C. elegans, homolog of, alpha antibody
    • Tax interacting protein 40 antibody
    • Tax interaction protein 40 antibody
    • TAX40 antibody
    • TIP 40 antibody
    • TIP-40 antibody
    • TIP40 antibody
    see all

Anti-PAR6 antibody (ab111823)参考文献

ab111823 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunohistochemistry (Frozen sections)
Sample Xenopus laevis Tissue sections (Embryo stage 26)
Permeabilization No
Specification Embryo stage 26
Blocking step Blocking reagent Perkin elmer as blocking agent for 30 minute(s) · Concentration: 1.5% · Temperature: 20°C
Fixative Paraformaldehyde
Username

Dr. Gerhard Schlosser

Verified customer

提交于 Mar 01 2016

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"