概述

  • 产品名称
    Papaverine
  • 描述
    Potent PDE inhibitor
  • 别名
    • NSC 136630
  • 生物学描述
    Potent PDE inhibitor. Partially selective for PDE10A (IC50 = 36 nM, 9-fold over other PDE isoforms). Inhibits cAMP and cGMP on smooth muscle cells causing vasodilation. Disrupts the blood-brain barrier causing increased cerebral blood flow.
  • 纯度
    > 98%

性能

文献

This product has been referenced in:
  • Zhang Z  et al. Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A. Eur J Med Chem 46:3986-95 (2011). Read more (PubMed: 21705115) »
  • Platz J  et al. Disruption of the blood-brain barrier by intra-arterial administration of papaverine: a technical note. Neuroradiology 50:1035-9 (2008). Read more (PubMed: 18791708) »
  • Zhao Y  et al. Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram. J Pharmacol Exp Ther 305:565-72 (2003). Read more (PubMed: 12704225) »

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