Mouse, Rat, Zebrafish
Recombinant fragment, corresponding to a region within amino acids 207-483 of Human PANK1.
293T, A431, H1299, HeLa S3, HepG2, Molt-4, Raji cells, NCIN87 xenograft
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
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Immunogen affinity purified
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/3000. Predicted molecular weight: 64 kDa.
1/100 - 1/500.
Plays a role in the physiological regulation of the intracellular CoA concentration.
Isoform 1 is expressed at high levels in brain, heart, kidney, liver, skeletal muscle and testis. Isoform 2 is detected at much lower levels in kidney, liver, brain and testis and is not detected in heart or skeletal muscle.
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.
Belongs to the type II pantothenate kinase family.
The N-terminal extension, present in isoform 1 may be the regulatory domain.
Information by UniProt
Western blot - PANK1 antibody (ab96173)
Anti-PANK1 antibody (ab96173) at 1/5000 dilution + HepG2 whole cell lysate at 30 µg
Predicted band size: 64 kDa 7.5% SDS PAGE
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PANK1 antibody (ab96173)
Immunohistochemical analysis of paraffin-embedded NCIN87 xenograft, using ab96173 at 1/500 dilution.
has not yet been referenced specifically in any publications.
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