Anti-pan Synuclein抗体(ab15534)

概述

  • 产品名称Anti-pan Synuclein抗体
    参阅全部 pan Synuclein 一抗
  • 描述
    兔多克隆抗体to pan Synuclein
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide within pan Synuclein (N terminal). The exact sequence is proprietary. A synthetic peptide corresponding to near N-terminal of human alpha, beta, gamma Synuclein protein.

  • 阳性对照
    • IHC-P: Human brain tissue.

性能

应用

Our Abpromise guarantee covers the use of ab15534 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 17 kDa.

Use at a concentration of 1 µg/ml for 2 hours at RT.

IHC-P 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
1/50 for 10 min at RT. Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

靶标

  • 相关性Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors. The family includes three known proteins: alpha, beta and gamma synucleins. Synuclein-alpha is primarily localized at the presynaptic region of axons and it may be involved in the regulation of dopamine release and transport. However, it can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Synuclein-alpha may induce fibrillization of the microtubule-associated protein tau and it reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Synuclein-alpha is involved in Parkinson's disease, Lewy body dementia, Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome) and it is a major non-amyloid component of the deposits associated with Alzheimer's disease. Synuclein-beta may be a regulator of the SNCA aggregation process. It protects neurons from staurosporine and 6 hydroxy dopamine (6OHDA)-stimulated caspase activation that also involves p53 and contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Gamma synuclein is found primarily in the peripheral nervous system and retina. High levels of expression have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development.
  • 细胞定位Neuronal cytosol and presynaptic terminals
  • 数据库链接
  • 别名
    • BCSG1 antibody
    • beta synuclein antibody
    • Breast cancer specific gene 1 protein antibody
    • Gamma synuclein antibody
    • NACP antibody
    • PARK1 antibody
    • Persyn antibody
    • PRSN antibody
    • SNCA antibody
    • SNCB antibody
    • SNCG antibody
    • SR antibody
    • Synoretin antibody
    see all

Anti-pan Synuclein antibody 图像

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human brain tissue labelling pan Synuclein with ab15534.

  • Human brain stained with ab15534

Anti-pan Synuclein antibody (ab15534)参考文献

ab15534 has not yet been referenced specifically in any publications.

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