Anti-pan Sodium Channel抗体(ab53724)
Key features and details
- Rabbit polyclonal to pan Sodium Channel
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-pan Sodium Channel抗体 -
描述
兔多克隆抗体to pan Sodium Channel -
宿主
Rabbit -
特异性
Detects endogenous levels of total sodium channel protein. -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Synthetic peptide corresponding to Human pan Sodium Channel.
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阳性对照
- Extracts from HuvEc cells.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, PBS
Without Mg+2 and Ca+2 -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab53724于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/1000. Detects a band of approximately 227 kDa (predicted molecular weight: 227 kDa).
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说明 |
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WB
1/500 - 1/1000. Detects a band of approximately 227 kDa (predicted molecular weight: 227 kDa). |
靶标
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相关性
The pan sodium ion channel, SCN5A, is a cardiac sodium channel distinct from those in nerve and muscle. It is a tetrodotoxin-resistant Na(+) channel isoform. SCN5A mediates the voltage-dependent sodium ion permeability of excitable membranes by opening or closing in response to the voltage difference across the membrane. Na(+) ions pass in accordance with their electrochemical gradient. This channel is responsible for the initial upstroke of the action potential in the electrocardiogram. Defects in SCN5A are involved in many diseases including: progressive familial heart block type I (PFHBI), also known as Lenegre-Lev disease or progressive cardiac conduction defect (PCCD); long QT syndrome type 3 (LQT3); Brugada syndrome; sick sinus syndrome 1 (SSS1); idiopathic ventricular fibrillation (IVF), also called paroxysmal familial ventricular fibrillation; sudden infant death syndrome (SIDS); familial atrial standstill and dilated cardiomyopathy 1E (CMD1E). -
细胞定位
Cell Membrane; Multi-pass membrane protein. -
数据库链接
- Entrez Gene: 6331 Human
- Entrez Gene: 20271 Mouse
- Entrez Gene: 25665 Rat
- Omim: 600163 Human
- SwissProt: P35498 Human
- SwissProt: P35499 Human
- SwissProt: Q14524 Human
- SwissProt: Q15858 Human
see all -
别名
- HBSC II antibody
- HH1 antibody
- hNaN antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab53724 被引用在 1 文献中.
- Demers J et al. Atrial Electrical Remodeling in Mice With Cardiac-Specific Overexpression of Angiotensin II Type 1 Receptor. J Am Heart Assoc 11:e023974 (2022). PubMed: 35435021