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Anti-PALB2抗体(ab38587)

概述

性能

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  • 功能Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures.
  • 疾病相关Note=Genetic variations in PALB2 are associated with breast cancer susceptibility.
    Defects in PALB2 are the cause of Fanconi anemia complementation group N (FANCN) [MIM:610832]. It is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
    Defects in PALB2 are the cause of pancreatic cancer type 3 (PNCA3) [MIM:613348]. It is a malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue.
  • 序列相似性Contains 7 WD repeats.
  • 结构域Interaction with BRCA2 occurs through a hydrophobic pocket at the crossover between WD repeats 4 and 5.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus. Colocalizes with BRCA2 in nuclear foci.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 4732427B05 antibody
    • BC066140 antibody
    • DKFZp667I166 antibody
    • DKFZp686E1054 antibody
    • FANCN antibody
    • FANCN GENE antibody
    • FLJ21816 antibody
    • OTTMUSP00000025884 antibody
    • PALB2 antibody
    • PALB2_HUMAN antibody
    • Partner and localizer of BRCA2 antibody
    • PNCA3 antibody
    • RGD1304759 antibody
    see all

Anti-PALB2 antibody (ab38587)参考文献

ab38587 has not yet been referenced specifically in any publications.

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Application Western blot
Sample Rat Tissue lysate - whole (Rat lung tissue)
Loading amount 50 µg
Specification Rat lung tissue
Gel Running Conditions Reduced Denaturing (8% gel)
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
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提交于 Apr 24 2009

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Application Western blot
Sample Human Cell lysate - whole cell (HeLa MCF7 U2OS)
Loading amount 20 µg
Specification HeLa MCF7 U2OS
Gel Running Conditions Reduced Denaturing
Blocking step BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 3% · Temperature: 21°C
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提交于 Mar 25 2009

Application Western blot
Sample Human Cell lysate - whole cell (breast cancer cell line)
Loading amount 30 µg
Specification breast cancer cell line
Gel Running Conditions Reduced Denaturing (8% gel)
Blocking step BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
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提交于 Oct 27 2008

Application Western blot
Sample Human Cell lysate - whole cell (MCF-7 cell)
Loading amount 50 µg
Specification MCF-7 cell
Gel Running Conditions Reduced Denaturing (4-20% gel)
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
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提交于 Jun 09 2008

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