Anti-PAIP2抗体(ab33455)

概述

• 产品名称
  Anti-PAIP2抗体
  参阅全部 PAIP2 一抗
• 描述
  兔多克隆抗体to PAIP2
• 经测试应用
  适用于: WBmore details
• 种属反应性
  与反应: Human
  预测可用于: Mouse, Rat, Chicken, Cow
• 免疫原

  Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human PAIP2.

  参阅Abcam的专有抗源政策

  (Peptide available as ab36582.)

• 阳性对照
  • This antibody gave a positive signal in the following whole cell lysates: Jurkat; A431; HEK293; SHSY-5Y.

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• 存储溶液
  Preservative: 0.02% Sodium Azide
  Constituents: 1% BSA, PBS, pH 7.4
• Concentration information loading...
• 纯度
  Immunogen affinity purified
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • Translation
  • Regulation

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

应用

靶标

• 功能
  Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.
• 序列相似性
  Belongs to the PAIP2 family.
• 结构域
  Only the PABPC1-interacting motif-1 (PAM1) interferes with the binding of PABPC1 to poly(A) RNA and translation initiation.
• 细胞定位
  Cytoplasm.

• Target information above from: UniProt accession Q9BPZ3 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 416187 Chicken
  • Entrez Gene: 536619 Cow
  • Entrez Gene: 51247 Human
  • Entrez Gene: 67869 Mouse
  • Entrez Gene: 361309 Rat
  • Omim: 605604 Human
  • SwissProt: Q5ZJS6 Chicken
  • SwissProt: Q3ZC67 Cow

  • SwissProt: Q9BPZ3 Human
  • SwissProt: Q9D6V8 Mouse
  • SwissProt: Q6AXZ0 Rat
  • Unigene: 396644 Human
  • Unigene: 126534 Mouse
  • Unigene: 1073 Rat

  see all
• 别名
  • PABP-interacting protein 2 antibody
  • PAIP-2 antibody
  • PAIP2 antibody

  • PAIP2_HUMAN antibody
  • poly(A) binding protein interacting protein 2 antibody
  • Poly(A)-binding protein-interacting protein 2 antibody
  • Polyadenylate-binding protein-interacting protein 2 antibody

  see all

实验方案

• Western blot protocols