Mouse, Rat, Horse, Cow, Dog, Rhesus monkey, Opossum
Recombinant fragment with tag: YPTLSEYVQD FLNHLTEQPG SFETEIEQFA ETLNGCVTTD DALQELVELI YQQATSIPNF SYMGARLCNY LSHHLTISPQ SGNFRQLLLQ RCRTEYEVKD QAAKGDEVTR , corresponding to amino acids 76-186 of Human PAIP1
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
应用说明ELISA: Use at an assay dependent dilution.
WB: 1/1000 - 1/2500. Predicted molecular weight: 54 kDa.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
功能Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.
序列相似性Contains 1 MIF4G domain.
结构域Only the PABPC1-interacting motif-1 (PAM1) stimulates translation initiation.