产品名称 Anti-PAG3抗体 参阅全部 PAG3 一抗
WB, IP more details
Horse, Chimpanzee, Gorilla, Orangutan
Synthetic peptide, corresponding to region within amino acids 900-950 of Human PAG3 (NP_003878.1).
HeLa and 293T whole cell lysates.
存放说明 Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
存储溶液 Preservative: 0.09% Sodium azide Constituent: 99% Tris citrate/phosphate Note: pH 7 to 8
Concentration information loading...
纯度 Immunogen affinity purified
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/2000 - 1/10000. Predicted molecular weight: 112 kDa.
Use at 2-10 µg/mg of lysate.
功能 Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration.
组织特异性 Detected in heart, brain, placenta, kidney, monocytes and pancreas.
序列相似性 Contains 2 ANK repeats. Contains 1 Arf-GAP domain. Contains 1 PH domain. Contains 1 SH3 domain.
结构域 The conserved Arg-464 in the Arf-GAP domain probably becomes part of the active site of bound small GTPases and is necessary for GTP hydrolysis.
翻译后修饰 Phosphorylated on tyrosine residues by SRC and PTK2B.
细胞定位 Cytoplasm. Golgi apparatus > Golgi stack membrane. Cell membrane. Colocalizes with F-actin and ARF6 in phagocytic cups.
Information by UniProt
AMAP 2 antibody
ANK repeat and PH domain-containing protein 2 antibody
Anti-PAG3 antibody (ab117760)参考文献
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"