概述

  • 产品名称Anti-PADI4 / PAD4抗体
    参阅全部 PADI4 / PAD4 一抗
  • 描述
    小鼠单克隆抗体to PADI4 / PAD4
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 2-111 of Human PADI4/ PAD4

性能

应用

Our Abpromise guarantee covers the use of ab57167 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.
    • 组织特异性Expressed in eosinophils and neutrophils, not expressed in peripheral monocytes or lymphocytes.
    • 疾病相关Genetic variations in PADI4 are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Note=Could have an important role in the pathogenesis of rheumatoid arthritis by increasing citrullination of proteins in rheumatoid arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break in tolerance to citrullinated peptides processed and presented in the appropriate HLA context.
    • 序列相似性Belongs to the protein arginine deiminase family.
    • 细胞定位Cytoplasm. Nucleus. Cytoplasmic granule. Cytoplasmic granules of eosinophils and neutrophils.
    • Information by UniProt
    • 数据库链接
    • 别名
      • EC 3.5.3.15 antibody
      • HL 60 PAD antibody
      • HL-60 PAD antibody
      • PAD 4 antibody
      • PAD antibody
      • PADI 4 antibody
      • PADI 5 antibody
      • PADI H protein antibody
      • Padi4 antibody
      • PADI4_HUMAN antibody
      • PADI5 antibody
      • PDI 4 antibody
      • PDI 5 antibody
      • PDI4 antibody
      • PDI5 antibody
      • Peptidyl arginine deiminase type IV antibody
      • Peptidyl arginine deiminase type V antibody
      • Peptidylarginine deiminase IV antibody
      • Protein arginine deiminase antibody
      • Protein arginine deiminase type 4 antibody
      • Protein arginine deiminase type IV antibody
      • Protein-arginine deiminase type IV antibody
      • Protein-arginine deiminase type-4 antibody
      see all

    Anti-PADI4 / PAD4 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57167 PADI4 / PAD4 antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

    Anti-PADI4 / PAD4 antibody (ab57167)参考文献

    This product has been referenced in:

    See 1 Publication for this product

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