概述

  • 产品名称
  • 描述
    兔多克隆抗体to PACS1
  • 经测试应用
    适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide corresponding to C terminal residues of human PACS1 (Phosphofurin acidic cluster sorting protein 1)

性能

应用

Our Abpromise guarantee covers the use of ab56072 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明
    ELISA: Use at an assay dependent dilution.
    WB: Use at a concentration of 1 µg/ml for 2hrs. Predicted molecular weight: 105 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN.
    • 疾病相关
      Mental retardation, autosomal dominant 17
    • 序列相似性
      Belongs to the PACS family.
    • 细胞定位
      Golgi apparatus, trans-Golgi network. Localizes in the perinuclear region, probably the TGN.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Cytosolic sorting protein PACS1 antibody
      • PACS 1 antibody
      • PACS-1 antibody
      • Pacs1 antibody
      • PACS1_HUMAN antibody
      • Phosphofurin acidic cluster sorting protein 1 antibody
      see all

    Anti-PACS1 antibody 图像



    • Predicted band size : 105 kDa

      Image from Yi L et al, J Biol Chem. 2010 Oct 1;285(40):30884-905. Epub 2010 Jul 9, Fig 4. DOI 10.1074/jbc.M110.135947

    实验方案

    Anti-PACS1 antibody (ab56072)参考文献

    This product has been referenced in:
    • Werneburg NW  et al. Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2 (PACS-2). J Biol Chem : (2012). WB ; Human . Read more (PubMed: 22645134) »
    • Yi L  et al. HIV-1 Nef binds a subpopulation of MHC-I throughout its trafficking itinerary and down-regulates MHC-I by perturbing both anterograde and retrograde trafficking. J Biol Chem 285:30884-905 (2010). WB ; Human . Read more (PubMed: 20622010) »

    See all 2 Publications for this product

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