概述

  • 产品名称Anti-PACRG抗体
    参阅全部 PACRG 一抗
  • 描述
    兔多克隆抗体to PACRG
  • 经测试应用适用于: WB, ELISA, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Zebrafish
  • 免疫原

    Synthetic peptide:

    NGSYSLPRLECS

    , corresponding to internal sequence amino acids 204-215 of Human PACRG, conjugated to KLH.

  • 阳性对照
    • Human colon tissue

性能

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应用

Our Abpromise guarantee covers the use of ab115465 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 33 kDa.
ELISA 1/2000 - 1/10000.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use at an assay dependent concentration.

靶标

  • 功能Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.
  • 组织特异性Expressed in all immune tissues, spleen, lymph nodes, thymus, tonsils, leukocyte and bone marrow. Expressed also in heart, brain, skeletal muscle, kidney, lung and pancreas. Expressed in primary Schwann cells and very weakly by monocyte-derived macrophages the primary host cells of Mycobacterium leprae, the causative agent of leprosy. Component of Lewy bodies, intraneuronal inclusions found in the brain of Parkinson disease patients.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ32724 antibody
    • GLUP antibody
    • HAK005771 antibody
    • Molecular chaperone/chaperonin binding protein antibody
    • Molecular chaperone/chaperonin-binding protein antibody
    • PACRG antibody
    • PACRG_HUMAN antibody
    • PARK 2 co regulated antibody
    • PARK 2 coregulated antibody
    • PARK2 co regulated antibody
    • PARK2 coregulated antibody
    • PARK2 coregulated gene protein antibody
    • PARK2CRG antibody
    • Parkin co regulated gene antibody
    • Parkin co regulated gene protein antibody
    • Parkin coregulated gene antibody
    • Parkin coregulated gene protein antibody
    • RP3 495O10.2 antibody
    see all

Anti-PACRG antibody 图像

  • ab115465, at 2.5 µg/ml, staining PACRG in formalin fixed, paraffin embedded Human colon tissue by Immunohistochemistry.

Anti-PACRG antibody (ab115465)参考文献

ab115465 has not yet been referenced specifically in any publications.

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