• 产品名称Anti-PACE4抗体
    参阅全部 PACE4 一抗
  • 描述
    小鼠单克隆抗体to PACE4
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 860-970 of Human PACE4



Our Abpromise guarantee covers the use of ab58226 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Likely to represent an endoprotease activity within the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues and capable of cleavage at the RX(K/R)R consensus motif.
    • 组织特异性Each PACE4 isoform exhibits a unique restricted distribution. Isoform PACE4A-I is expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, but at comparatively higher levels in the liver. Isoform PACE4A-II is at least expressed in placenta. Isoform PACE4B was only found in the embryonic kidney cell line from which it was isolated. Isoform PACE4C and isoform PACE4D are expressed in placenta. Isoform PACE4E-I is expressed in cerebellum, placenta and pituitary. Isoform PACE4E-II is at least present in cerebellum.
    • 序列相似性Belongs to the peptidase S8 family.
      Contains 1 homo B/P domain.
      Contains 1 PLAC domain.
    • 结构域The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum. Isoform PACE4D lacks the propeptide domain.
    • 细胞定位Secreted; Endomembrane system. Retained intracellularly probably through a hydrophobic cluster in their C-terminus and Endoplasmic reticulum. Not secreted, remains probably in zymogen form in endoplasmic reticulum.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Paired basic amino acid cleaving enzyme 4 antibody
      • Paired basic amino acid cleaving system 4 antibody
      • PCSK6 antibody
      • PCSK6_HUMAN antibody
      • Proprotein convertase subtilisin/kexin type 6 antibody
      • SPC4 antibody
      • Subtilisin like protease antibody
      • Subtilisin-like proprotein convertase 4 antibody
      • subtilisin/kexin like protease PACE4 antibody
      • Subtilisin/kexin-like protease PACE4 antibody
      see all

    Anti-PACE4 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab58226 PACE4 antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

    Anti-PACE4 antibody (ab58226)参考文献

    ab58226 has not yet been referenced specifically in any publications.

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    We unfortunately haven't tested this antibody with endogenous lysates so I am sorry we do not have data for comparison. However as this antibody has passed the qc test so it should be able to detect the protein. I app...

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