Anti-APP-1抗体(ab76763)
Key features and details
- Rabbit polyclonal to APP-1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-APP-1抗体
参阅全部 APP-1 一抗 -
描述
兔多克隆抗体to APP-1 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Synthetic peptide corresponding to Human APP-1 (internal sequence).
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Constituent: Whole serum -
Concentration information loading...
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纯度
Whole antiserum -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab76763于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/5000. Predicted molecular weight: 71 kDa.
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说明 |
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WB
1/500 - 1/5000. Predicted molecular weight: 71 kDa. |
靶标
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功能
Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. -
组织特异性
Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated. -
序列相似性
Belongs to the polyadenylate-binding protein type-1 family.
Contains 1 PABC domain.
Contains 4 RRM (RNA recognition motif) domains. -
翻译后修饰
Arg-518 is dimethylated, probably to asymmetric dimethylarginine. -
细胞定位
Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. - Information by UniProt
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数据库链接
- Entrez Gene: 8761 Human
- Entrez Gene: 230721 Mouse
- Entrez Gene: 298510 Rat
- Omim: 603407 Human
- SwissProt: Q13310 Human
- Unigene: 169900 Human
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别名
- Activated platelet protein 1 antibody
- Activated-platelet protein 1 antibody
- APP 1 antibody
see all
数据表及文件
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Datasheet download
文献 (1)
ab76763 被引用在 1 文献中.
- Jiang L et al. MicroRNA-144 targets APP to regulate AML1/ETO+ leukemia cell migration via the p-ERK/c-Myc/MMP-2 pathway. Oncol Lett 18:2034-2042 (2019). PubMed: 31423275