Anti-p75 NGF Receptor抗体[MLR2] (ab61425)


  • 产品名称Anti-p75 NGF Receptor抗体[MLR2]
    参阅全部 p75 NGF Receptor 一抗
  • 描述
    小鼠单克隆抗体[MLR2] to p75 NGF Receptor
  • 经测试应用适用于: Flow Cyt, ELISA, Competitive ELISA, ICC/IFmore details
    不适用于: WB
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Human p75 coupled to an Fc fragment

  • 阳性对照
    • Motor neurons in spinal cord with lesioned sciatic nerve



Our Abpromise guarantee covers the use of ab61425 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use a concentration of 20 µg/ml. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
ELISA 1/5000.
Competitive ELISA Use at an assay dependent concentration. PubMed: 22292018
ICC/IF Use at an assay dependent concentration.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
    • 序列相似性Contains 1 death domain.
      Contains 4 TNFR-Cys repeats.
    • 结构域Death domain is responsible for interaction with RANBP9.
      The extracellular domain is responsible for interaction with NTRK1.
    • 翻译后修饰N- and O-glycosylated.
      O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.
      Phosphorylated on serine residues.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CD271 antibody
      • CD271 antigen antibody
      • Gp80 LNGFR antibody
      • Gp80-LNGFR antibody
      • Low affinity nerve growth factor receptor antibody
      • Low affinity neurotrophin receptor p75NTR antibody
      • Low-affinity nerve growth factor receptor antibody
      • Nerve growth factor receptor antibody
      • Nerve growth factor receptor TNFR superfamily member 16 antibody
      • NGF receptor antibody
      • Ngfr antibody
      • p75 ICD antibody
      • p75 Neurotrophin receptor antibody
      • p75 NTR antibody
      • p75(NTR) antibody
      • p75NTR antibody
      • TNFR Superfamily Member 16 antibody
      • TNFRSF16 antibody
      • TNR16_HUMAN antibody
      • Tumor necrosis factor receptor superfamily member 16 antibody
      see all

    Anti-p75 NGF Receptor antibody [MLR2] 图像

    • Ab61425 uptake into mesenteric nerves following in vivo administration into adult rat.

    Anti-p75 NGF Receptor antibody [MLR2] (ab61425)参考文献

    This product has been referenced in:
    • Zhang C  et al. Suppression of p75 Neurotrophin Receptor Surface Expression with Intrabodies Influences Bcl-xL mRNA Expression and Neurite Outgrowth in PC12 Cells. PLoS One 7:e30684 (2012). Competitive ELISA . Read more (PubMed: 22292018) »
    • Huh CY  et al. Chronic exposure to nerve growth factor increases acetylcholine and glutamate release from cholinergic neurons of the rat medial septum and diagonal band of Broca via mechanisms mediated by p75NTR. J Neurosci 28:1404-9 (2008). Read more (PubMed: 18256260) »

    See all 5 Publications for this product

    Product Wall

    Thanks for your phone call last week and for your patience while I have been in touch with the lab about ab61425. I apologize for the delay in getting back to you. I was told that this antibody was generated against the extracellular domain of ...

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