概述

  • 产品名称Anti-p75 NGF Receptor抗体
    参阅全部 p75 NGF Receptor 一抗
  • 描述
    山羊多克隆抗体to p75 NGF Receptor
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human, Zebrafish
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide:

    C-AKREEVEKLLNG

    , corresponding to amino acids 342-353 of Human p75 NGF Receptor.

  • 阳性对照
    • WB: Human Duodenum and Human Heart lysates.

性能

应用

Our Abpromise guarantee covers the use of ab32888 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明ELISA: 1/32000.
    WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 75 kDa (predicted molecular weight: 45 kDa). The observed molecular weight corresponds to earlier findings in literature (see reference provided).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
    • 序列相似性Contains 1 death domain.
      Contains 4 TNFR-Cys repeats.
    • 结构域Death domain is responsible for interaction with RANBP9.
      The extracellular domain is responsible for interaction with NTRK1.
    • 翻译后修饰N- and O-glycosylated.
      O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.
      Phosphorylated on serine residues.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CD271 antibody
      • CD271 antigen antibody
      • Gp80 LNGFR antibody
      • Gp80-LNGFR antibody
      • Low affinity nerve growth factor receptor antibody
      • Low affinity neurotrophin receptor p75NTR antibody
      • Low-affinity nerve growth factor receptor antibody
      • Nerve growth factor receptor antibody
      • Nerve growth factor receptor TNFR superfamily member 16 antibody
      • NGF receptor antibody
      • Ngfr antibody
      • p75 ICD antibody
      • p75 Neurotrophin receptor antibody
      • p75 NTR antibody
      • p75(NTR) antibody
      • p75NTR antibody
      • TNFR Superfamily Member 16 antibody
      • TNFRSF16 antibody
      • TNR16_HUMAN antibody
      • Tumor necrosis factor receptor superfamily member 16 antibody
      see all

    Anti-p75 NGF Receptor antibody 图像

    • Anti-p75 NGF Receptor antibody (ab32888) at 0.3 µg/ml + Human Heart lysate in RIPA buffer at 35 µg
      Developed using the ECL technique

      Predicted band size : 45 kDa
      Observed band size : 75 kDa (why is the actual band size different from the predicted?)


      Exposure time : 1 hour

    Anti-p75 NGF Receptor antibody (ab32888)参考文献

    This product has been referenced in:
    • Han HW  et al. The Nogo-C2/Nogo receptor complex regulates the morphogenesis of zebrafish lateral line primordium through modulating the expression of dkk1b, a Wnt signal inhibitor. PLoS One 9:e86345 (2014). WB ; Zebrafish . Read more (PubMed: 24466042) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"