概述

  • 产品名称Anti-p75 NGF Receptor抗体
    参阅全部 p75 NGF Receptor 一抗
  • 描述
    兔多克隆抗体to p75 NGF Receptor
  • 特异性ab25958 recognises NGFR (p75NTR, TNFRSF16).
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Recombinant full length human NGFR

  • 阳性对照
    • A-20 cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab25958 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 80 kDa.
ICC/IF Use a concentration of 10 µg/ml.

靶标

  • 功能Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
  • 序列相似性Contains 1 death domain.
    Contains 4 TNFR-Cys repeats.
  • 结构域Death domain is responsible for interaction with RANBP9.
    The extracellular domain is responsible for interaction with NTRK1.
  • 翻译后修饰N- and O-glycosylated.
    O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.
    Phosphorylated on serine residues.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD271 antibody
    • CD271 antigen antibody
    • Gp80 LNGFR antibody
    • Gp80-LNGFR antibody
    • Low affinity nerve growth factor receptor antibody
    • Low affinity neurotrophin receptor p75NTR antibody
    • Low-affinity nerve growth factor receptor antibody
    • Nerve growth factor receptor antibody
    • Nerve growth factor receptor TNFR superfamily member 16 antibody
    • NGF receptor antibody
    • Ngfr antibody
    • p75 ICD antibody
    • p75 Neurotrophin receptor antibody
    • p75 NTR antibody
    • p75(NTR) antibody
    • p75NTR antibody
    • TNFR Superfamily Member 16 antibody
    • TNFRSF16 antibody
    • TNR16_HUMAN antibody
    • Tumor necrosis factor receptor superfamily member 16 antibody
    see all

Anti-p75 NGF Receptor antibody 图像

  • Immunocytochemistry/ Immunofluorescence of HCEM cells labelling p75 NGF Receptor (green) with ab25958 at 1/500. Cells were cultured until low confluence on 35mm glass base dishes and washed with PBS. Cells were fixed with 4% paraformaldehyde in PBS and blocked by incubation with TBS containing 0.2% casein and 0.1% Triton X-100 for 20 minutes. Cells were incubated with primary antibody (1/500) overnight at 4°C. An Alexa Fluor® 488 anti-rabbit IgG (1/200) was used as the secondary antibody. Beta actin was stained with Alexa Fluor® 594 phalloidin (red).

  • ab25958 at 10µg/ml staining p75NGF Receptor in A20 cells by ICC/IF

Anti-p75 NGF Receptor antibody (ab25958)参考文献

This product has been referenced in:
  • Kajiya M  et al. Brain-derived neurotrophic factor stimulates bone/cementum-related protein gene expression in cementoblasts. J Biol Chem 283:16259-67 (2008). WB, ICC/IF ; Human . Read more (PubMed: 18390540) »

See 1 Publication for this product

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