概述

  • 产品名称Anti-p73抗体
    参阅全部 p73 一抗
  • 描述
    兔多克隆抗体to p73
  • 特异性ab70093 detects endogenous levels of total p73 protein.
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide derived from an internal sequence of human p73.

  • 阳性对照
    • WB: Jurkat cell extract IHC-P: Human brain tissue

性能

应用

Our Abpromise guarantee covers the use of ab70093 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 70 kDa (predicted molecular weight: 70 kDa).
ELISA 1/40000.
IHC-P Use at an assay dependent concentration.

靶标

  • 功能Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
  • 组织特异性Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue.
  • 序列相似性Belongs to the p53 family.
    Contains 1 SAM (sterile alpha motif) domain.
  • 结构域Possesses an acidic transactivation domain, a central DNA binding domain and a C-terminal oligomerization domain that binds to the ABL tyrosine kinase SH3 domain.
    The WW-binding motif mediates interaction with WWOX.
  • 翻译后修饰Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does not affect transcriptional activity.
    Higher levels of phosphorylation seen in the brain from patients with Huntington disease.
    Ubiquitinated; leading to its degradation by the proteasome.
  • 细胞定位Nucleus. Accumulates in the nucleus in response to DNA damage.
  • Information by UniProt
  • 数据库链接
  • 别名
    • p53 like transcription factor antibody
    • p53 related protein antibody
    • p53-like transcription factor antibody
    • p53-related protein antibody
    • p73 antibody
    • P73_HUMAN antibody
    • TP73 antibody
    • Tumor protein p73 antibody
    see all

Anti-p73 antibody 图像

  • ab70093, at 1/50 dilution, staining p73 in paraffin embedded human brain tissue by Immunohistochemistry in the absence or presence of the immunising peptide.
  • All lanes : Anti-p73 antibody (ab70093) at 1/500 dilution

    Lane 1 : Jurkat cell extract
    Lane 2 : Jurkat cell extract with immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 70 kDa
    Observed band size : 70 kDa

Anti-p73 antibody (ab70093)参考文献

ab70093 has not yet been referenced specifically in any publications.

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