Anti-p63 (phospho S395)抗体(ab92581)


  • 产品名称Anti-p63 (phospho S395)抗体
    参阅全部 p63 一抗
  • 描述
    兔多克隆抗体to p63 (phospho S395)
  • 特异性ab92581 detects endogenous levels of p63 only when phosphorylated at serine 395.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthesized phosphopeptide derived from Human p63 around the phosphorylation site of serine 395 (R-R-SP-P-D).

  • 阳性对照
    • HepG2, A549 and LOVO cell extracts treated with nocodazole (1 µg/ml, 18 hours)



Our Abpromise guarantee covers the use of ab92581 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明ELISA: 1/40,000.
    WB: 1/500 - 1/1000. Predicted molecular weight: 77 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge.
    • 组织特异性Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.
    • 疾病相关Defects in TP63 are the cause of acro-dermato-ungual-lacrimal-tooth syndrome (ADULT syndrome) [MIM:103285]; a form of ectodermal dysplasia. Ectodermal dysplasias (EDs) constitute a heterogeneous group of developmental disorders affecting tissues of ectodermal origin. EDs are characterized by abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia. ADULT syndrome involves ectrodactyly, syndactyly, finger- and toenail dysplasia, hypoplastic breasts and nipples, intensive freckling, lacrimal duct atresia, frontal alopecia, primary hypodontia, and loss of permanent teeth. ADULT differs significantly from EEC3 syndrome by the absence of facial clefting.
      Defects in TP63 are the cause of ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) [MIM:106260]. AEC is an autosomal dominant condition characterized by congenital ectodermal dysplasia with coarse, wiry, sparse hair, dystrophic nails, slight hypohidrosis, scalp infections, ankyloblepharon filiform adnatum, maxillary hypoplasia, hypodontia and cleft lip/palate.
      Defects in TP63 are the cause of ectrodactyly-ectodermal dysplasia-cleft lip/palate syndrome type 3 (EEC3) [MIM:604292]. EEC3 is an autosomal dominant syndrome characterized by ectrodactyly of hands and feet, ectodermal dysplasia and facial clefting.
      Defects in TP63 are the cause of split-hand/foot malformation type 4 (SHFM4) [MIM:605289]. Split-hand/split-foot malformation is a limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. There is restricted overlap between the mutational spectra of EEC3 and SHFM4.
      Defects in TP63 are the cause of limb-mammary syndrome (LMS) [MIM:603543]. LMS is characterized by ectrodactyly, cleft palate and mammary-gland abnormalities.
      Note=Defects in TP63 are a cause of cervical, colon, head and neck, lung and ovarian cancers.
      Defects in TP63 are a cause of ectodermal dysplasia Rapp-Hodgkin type (EDRH) [MIM:129400]; also called Rapp-Hodgkin syndrome or anhidrotic ectodermal dysplasia with cleft lip/palate. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDRH is characterized by the combination of anhidrotic ectodermal dysplasia, cleft lip, and cleft palate. The clinical syndrome is comprised of a characteristic facies (narrow nose and small mouth), wiry, slow-growing, and uncombable hair, sparse eyelashes and eyebrows, obstructed lacrimal puncta/epiphora, bilateral stenosis of external auditory canals, microsomia, hypodontia, cone-shaped incisors, enamel hypoplasia, dystrophic nails, and cleft lip/cleft palate.
      Defects in TP63 are the cause of non-syndromic orofacial cleft type 8 (OFC8) [MIM:129400]. Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.
    • 序列相似性Belongs to the p53 family.
      Contains 1 SAM (sterile alpha motif) domain.
    • 结构域The transactivation inhibitory domain (TID) can interact with, and inhibit the activity of the N-terminal transcriptional activation domain of TA*-type isoforms.
    • 翻译后修饰May be sumoylated.
      Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
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      • p40 antibody
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      • p53-related protein p63 antibody
      • p53CP antibody
      • p63 antibody
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      • p73H antibody
      • p73L antibody
      • RHS antibody
      • SHFM4 antibody
      • TAp63alpha antibody
      • TP53CP antibody
      • TP53L antibody
      • TP63 antibody
      • TP73L antibody
      • Transformation related protein 63 antibody
      • Transformation-related protein 63 antibody
      • Trp53rp1 antibody
      • Trp63 antibody
      • Tumor protein 63 antibody
      • Tumor protein p53-competing protein antibody
      • Tumor protein p53-like antibody
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      • Tumor protein p73-like antibody
      see all

    Anti-p63 (phospho S395) antibody 图像

    • All lanes : Anti-p63 (phospho S395) antibody (ab92581) at 1/500 dilution

      Lane 1 : Extracts from HepG2 cells treated with nocodazole (1 µg/ml, 18 hours)
      Lane 2 : Extracts from A549 cells treated with nocodazole (1 µg/ml, 18 hours)
      Lane 3 : Extracts from LOVO cells treated with nocodazole (1 µg/ml, 18 hours)
      Lane 4 : Extracts from HepG2 cells treated with nocodazole (1 µg/ml, 18 hours) with immunizing peptide at 10 µg

      Lysates/proteins at 30 µg per lane.

      Predicted band size : 77 kDa

    Anti-p63 (phospho S395) antibody (ab92581)参考文献

    ab92581 has not yet been referenced specifically in any publications.

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