概述

  • 产品名称Anti-P5CS抗体
    参阅全部 P5CS 一抗
  • 描述
    山羊多克隆抗体to P5CS
  • 特异性ab106807 is expected to recognize both reported isoforms (NP_002851.2; NP_001017423.1).
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat, Horse, Cow, Dog, Pig
  • 免疫原

    Synthetic peptide:

    C-SEHGSLKYLH

    , corresponding to C terminal amino acids 775-784 of Human P5CS (NP_002851.2).

  • 阳性对照
    • MCF7 cell lysate
  • 常规说明


性能

应用

Our Abpromise guarantee covers the use of ab106807 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 85 kDa (predicted molecular weight: 87 kDa).

靶标

  • 通路Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.
    Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.
  • 疾病相关Defects in ALDH18A1 are the cause of mental retardation-joint hypermobility-skin laxity with or without metabolic abnormalities (MRJHSL) [MIM:612652]. Clinical manifestations include microcephaly, progressive neurologic dysfunction, mental retardation, progeroid appearance, joint hypermobility, skin laxity and hyperelasticity, cataracts. Some patients manifest metabolic disturbances such as hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia.
  • 序列相似性In the N-terminal section; belongs to the glutamate 5-kinase family.
    In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.
  • 细胞定位Mitochondrion inner membrane.
  • Information by UniProt
  • 数据库链接
  • 形式P5CS catalyzes the ATP- and NADPH-dependent conversion of L-glutamate to glutamic gamma-semialdehyde, which is the metabolic precursor for proline biosynthesis. There are 2 isoforms produced by alternative splicing.
  • 别名
    • 2810433K04Rik antibody
    • AI429789 antibody
    • Aldehyde dehydrogenase 18 family member A1 antibody
    • Aldehyde dehydrogenase 18A1 antibody
    • Aldehyde dehydrogenase family 18 member A1 antibody
    • ALDH18A1 antibody
    • Delta 1 pyrroline 5 carboxylate synthetase antibody
    • Delta1 pyrroline 5 carboxlate synthetase antibody
    • Gamma-glutamyl kinase antibody
    • Gamma-glutamyl phosphate reductase antibody
    • GK antibody
    • Glutamate-5-semialdehyde dehydrogenase antibody
    • Glutamyl-gamma-semialdehyde dehydrogenase antibody
    • GPR antibody
    • GSAS antibody
    • MGC117316 antibody
    • MGC32233 antibody
    • P5CS antibody
    • P5CS_HUMAN antibody
    • PYCS antibody
    • Pyrroline 5 carboxylate synthetase (glutamate gamma semialdehyde synthetase) antibody
    see all

Anti-P5CS antibody 图像

  • Anti-P5CS antibody (ab106807) at 0.300000011921 µg/ml + Mouse NIH3T3 cell Lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 87 kDa
  • Anti-P5CS antibody (ab106807) at 1 µg/ml + MCF7 cell lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 87 kDa
    Primary incubation was 1 hour.

Anti-P5CS antibody (ab106807)参考文献

ab106807 has not yet been referenced specifically in any publications.

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