Anti-p57 Kip2 (phospho T310)抗体(ab61064)

概述

  • 产品名称Anti-p57 Kip2 (phospho T310)抗体
    参阅全部 p57 Kip2 一抗
  • 描述
    兔多克隆抗体to p57 Kip2 (phospho T310)
  • 特异性Ab61064 detects endogenous levels of p57 Kip2 only when phosphorylated at threonine 310.
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthesized phosphopeptide derived from human p57 Kip2 around the phosphorylation site of threonine 310(E-Q-TP-P-R).

  • 阳性对照
    • Human placenta tissue

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab61064 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 32 kDa.
ELISA 1/5000.
IHC-P 1/50 - 1/100.

靶标

  • 功能Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
  • 组织特异性Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver.
  • 疾病相关Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.
    Note=Defects in CDKN1C are involved in tumor formation.
  • 序列相似性Belongs to the CDI family.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Beckwith Wiedemann syndrome antibody
    • BWCR antibody
    • BWS antibody
    • CDKI antibody
    • CDKN 1C antibody
    • CDKN1C antibody
    • CDN1C_HUMAN antibody
    • Cyclin dependent kinase inhibitor 1C antibody
    • Cyclin dependent kinase inhibitor p57 antibody
    • Cyclin-dependent kinase inhibitor 1C antibody
    • Cyclin-dependent kinase inhibitor p57 antibody
    • KIP 2 antibody
    • KIP2 antibody
    • p57 antibody
    • p57 Kip 2 antibody
    • p57KIP2 antibody
    • WBS antibody
    see all

Anti-p57 Kip2 (phospho T310) antibody 图像

  • Immunohistochemistry analysis of paraffin-embedded human placenta tissue using ab61064 at 1/50-1/100 dilution with or without addition of Phospho-peptide.


  • Predicted band size : 32 kDa

    Western Blot analysis of K562 cell lysates labeling p57 Kip2 (phospho T310) with ab61064 at 0.01U/ml for 15 minutes. The lane on the right is blocked with the phospho peptide.

Anti-p57 Kip2 (phospho T310) antibody (ab61064)参考文献

ab61064 has not yet been referenced specifically in any publications.

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