Chen J et al.Overexpression of p53R2 is associated with poor prognosis in lung sarcomatoid carcinoma.BMC Cancer 17:855 (2017).
PubMed: 29246119
Narayanaswamy PB et al.Transcriptomic pathway analysis of urokinase receptor silenced breast cancer cells: a microarray study.Oncotarget 8:101572-101590 (2017).
PubMed: 29254187
Kuny CV & Kalejta RF Human Cytomegalovirus Can Procure Deoxyribonucleotides for Viral DNA Replication in the Absence of Retinoblastoma Protein Phosphorylation.J Virol 90:8634-43 (2016).
PubMed: 27440891
Cilli P et al.Oxidized dNTPs and the OGG1 and MUTYH DNA glycosylases combine to induce CAG/CTG repeat instability.Nucleic Acids Res 44:5190-203 (2016).
WB
.
PubMed: 26980281
Marthandan S et al.Conserved Senescence Associated Genes and Pathways in Primary Human Fibroblasts Detected by RNA-Seq.PLoS One 11:e0154531 (2016).
WB
.
PubMed: 27140416
Tebbi A et al.Caspase-dependent Proteolysis of Human Ribonucleotide Reductase Small Subunits R2 and p53R2 during Apoptosis.J Biol Chem 290:14077-90 (2015).
PubMed: 25878246
Specks J et al.A Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development.Mol Cell Biol 35:2910-7 (2015).
PubMed: 26077802
Graindorge D et al.Singlet Oxygen-Mediated Oxidation during UVA Radiation Alters the Dynamic of Genomic DNA Replication.PLoS One 10:e0140645 (2015).
WB
;
Human
.
PubMed: 26485711
Morgenroth A et al.Breaking the invulnerability of cancer stem cells: two-step strategy to kill the stem-like cell subpopulation of multiple myeloma.Mol Cancer Ther 13:144-53 (2014).
PubMed: 24174494
Allouch A et al.p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway.Proc Natl Acad Sci U S A 110:E3997-4006 (2013).
PubMed: 24082141
Chandra S et al.Enhancement of c-Myc degradation by BLM helicase leads to delayed tumor initiation.J Cell Sci 126:3782-95 (2013).
PubMed: 23750012
Kunos C et al.Ribonucleotide reductase inhibition restores platinum-sensitivity in platinum-resistant ovarian cancer: a Gynecologic Oncology Group Study.J Transl Med 10:79 (2012).
IHC-P
;
Human
.
PubMed: 22541066
Pontarin G et al.Deoxyribonucleotide Metabolism in Cycling and Resting Human Fibroblasts with a Missense Mutation in p53R2, a Subunit of Ribonucleotide Reductase.J Biol Chem 286:11132-40 (2011).
WB
;
Human
.
PubMed: 21297166
Pitceathly RD et al.Kearns-Sayre syndrome caused by defective R1/p53R2 assembly.J Med Genet : (2011).
WB
;
Human
.
PubMed: 21378381
Fyrberg A & Lotfi K Optimization and evaluation of electroporation delivery of siRNA in the human leukemic CEM cell line.Cytotechnology 62:497-507 (2010).
PubMed: 20957432
Tyynismaa H et al.A heterozygous truncating mutation in RRM2B causes autosomal-dominant progressive external ophthalmoplegia with multiple mtDNA deletions.Am J Hum Genet 85:290-5 (2009).
PubMed: 19664747
Park JY et al.p53 improves aerobic exercise capacity and augments skeletal muscle mitochondrial DNA content.Circ Res 105:705-12, 11 p following 712 (2009).
WB
;
Mouse
.
PubMed: 19696408
Pontarin G et al.Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage.Proc Natl Acad Sci U S A 105:17801-6 (2008).
WB, ICC/IF
;
Human
.
PubMed: 18997010
Bourdon A et al.Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion.Nat Genet 39:776-80 (2007).
PubMed: 17486094
Pontarin G et al.p53R2-dependent ribonucleotide reduction provides deoxyribonucleotides in quiescent human fibroblasts in the absence of induced DNA damage.J Biol Chem 282:16820-8 (2007).
PubMed: 17416930
Mansson E et al.Down-regulation of deoxycytidine kinase in human leukemic cell lines resistant to cladribine and clofarabine and increased ribonucleotide reductase activity contributes to fludarabine resistance.Biochem Pharmacol 65:237-47 (2003).
PubMed: 12504799
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