概述

  • 产品名称Anti-p53 BP3抗体
    参阅全部 p53 BP3 一抗
  • 描述
    小鼠单克隆抗体to p53 BP3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 98-206 of Human p53 BP3

性能

应用

Our Abpromise guarantee covers the use of ab56640 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.
    • 组织特异性Expressed at highest levels in testis and at lower levels in adrenal gland, bone marrow, brain, colon, heart, kidney, liver, muscle, ovary, pancreas, placenta, prostate, skeletal muscle, skin, small intestine, spleen, stomach, testis, thymus, thyroid and uterus. Expressed in the alveolar epithelium of the lung. Expression is commonly decreased in colon adenocarcinomas and lung cancers.
    • 疾病相关Defects in TOPORS are the cause of retinitis pigmentosa type 31 (RP31) [MIM:609923]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP31 inheritance is autosomal dominant.
    • 序列相似性Contains 1 RING-type zinc finger.
    • 翻译后修饰Phosphorylation at Ser-98 regulates the E3 ubiquitin-protein ligase activity but not the SUMO1-protein ligase activity. Phosphorylation at Ser-718 increases the E3 ubiquitin-protein ligase activity versus the SUMO1-protein ligase activity resulting in increased p53/TP53 ubiquitination and degradation.
      Sumoylated.
    • 细胞定位Nucleus. Nucleus > PML body. Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AW105885 antibody
      • E3 ubiquitin protein ligase Topors antibody
      • E3 ubiquitin-protein ligase Topors antibody
      • LUN antibody
      • p53 binding protein 3 antibody
      • p53 BP3/LUN antibody
      • p53-binding protein 3 antibody
      • p53BP3 antibody
      • p53BP3/LUN antibody
      • Retinitis pigmentosa 31 antibody
      • RP31 antibody
      • SUMO1 protein E3 ligase Topors antibody
      • SUMO1-protein E3 ligase Topors antibody
      • Topoisomerase I binding arginine/serine rich antibody
      • Topoisomerase I binding arginine/serine rich protein antibody
      • Topoisomerase I binding protein antibody
      • Topoisomerase I binding RING finger protein antibody
      • Topoisomerase I-binding arginine/serine-rich protein antibody
      • Topoisomerase I-binding RING finger protein antibody
      • Topoisomerase I-binding RS protein antibody
      • Topors antibody
      • TOPRS_HUMAN antibody
      • TP53BPL antibody
      • Tumor protein p53 binding protein antibody
      • Tumor suppressor p53 binding protein 3 antibody
      • Tumor suppressor p53-binding protein 3 antibody
      see all

    Anti-p53 BP3 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56640 p53 BP3 antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

    Anti-p53 BP3 antibody (ab56640)参考文献

    ab56640 has not yet been referenced specifically in any publications.

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