概述

  • 产品名称Anti-p51B抗体
  • 描述
    兔多克隆抗体to p51B
  • 特异性This antibody is specific for p51B. It does not cross react with p51A
  • 经测试应用适用于: ICC, WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide:

    CNFDMDARRNKQQRIKEEGE

    , corresponding to C terminal amino acids 662-680 of Human p51B.

  • 阳性对照
    • Human Cell Line K562.

性能

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应用

Our Abpromise guarantee covers the use of ab2505 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC 1/300.
WB 1/1000. Detects a band of approximately 55 kDa (predicted molecular weight: 51 kDa).

靶标

  • 相关性p51 acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of TP53/p53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge.
  • 细胞定位Nuclear
  • 数据库链接
  • 别名
    • AIS antibody
    • p51 antibody
    • p63 antibody
    • TP63 antibody
    • Tumor protein p53 like antibody
    • Tumor protein p63 antibody
    • Tumor protein p73 like antibody
    see all

Anti-p51B antibody 图像



  • Predicted band size : 51 kDa


    ab2505 detects an approximately 75kDa protein in mouse lung. As expected, most of the p51B protein in the human K562 tumour cell line is degraded.

Anti-p51B antibody (ab2505)参考文献

ab2505 has not yet been referenced specifically in any publications.

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