概述

  • 产品名称Anti-P2RY5抗体
    参阅全部 P2RY5 一抗
  • 描述
    兔多克隆抗体to P2RY5
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 113-142 of Human P2RY5 (NP_001155969.1, NP_005758.2, NP_001155970.1).

  • 阳性对照
    • Mouse heart tissue lysates

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab113055 was purified through a protein A column, followed by peptide affinity purification.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab113055 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 39 kDa.

靶标

  • 功能Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.
  • 组织特异性Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes.
  • 疾病相关Defects in LPAR6 are the cause of woolly hair autosomal recessive type 1 (ARWH1) [MIM:278150]. A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrexis nodosa and tapered ends.
    Defects in LPAR6 are the cause of hypotrichosis localized autosomal recessive type 3 (LAH3) [MIM:611452]. A condition characterized by the presence of less than the normal amount of hair. Affected individuals show progressive hair loss, thinning of scalp hair since early childhood, sparse body hair, and sparse eyebrows and eyelashes in some cases.
  • 序列相似性Belongs to the G-protein coupled receptor 1 family.
  • 发展阶段Markedly up-regulated in promyelocytic HL60 cells induced to differentiate along the monocyte/macrophage pathway. Not detectable in undifferentiated HL60 cells and only low levels after the induction of differentiation along the granulocytic pathway.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ARWH1 antibody
    • G protein coupled purinergic receptor P2Y5 antibody
    • LAH 3 antibody
    • LAH3 antibody
    • LPA receptor 6 antibody
    • LPA-6 antibody
    • LPAR 6 antibody
    • Lpar6 antibody
    • LPAR6_HUMAN antibody
    • Lysophosphatidic acid receptor 6 antibody
    • MGC 120358 antibody
    • MGC120358 antibody
    • Oleoyl L alpha lysophosphatidic acid receptor antibody
    • Oleoyl-L-alpha-lysophosphatidic acid receptor antibody
    • P 2 RY 5 antibody
    • p2ry5 antibody
    • P2Y purinoceptor 5 antibody
    • P2Y5 antibody
    • Purinergic receptor 5 antibody
    • purinergic receptor P2Y, G protein coupled, 5 antibody
    • purinergic receptor p2y5 antibody
    • RB intron encoded G protein coupled receptor antibody
    • RB intron encoded G-protein coupled receptor antibody
    see all

Anti-P2RY5 antibody 图像

  • Anti-P2RY5 antibody (ab113055) at 1/100 dilution + Mouse heart tissue lysates at 35 µg

    Predicted band size : 39 kDa

Anti-P2RY5 antibody (ab113055)参考文献

This product has been referenced in:
  • Brünnert D  et al. Lysophosphatidic acid and sphingosine 1-phosphate metabolic pathways and their receptors are differentially regulated during decidualization of human endometrial stromal cells. Mol Hum Reprod N/A:N/A (2014). Read more (PubMed: 24994816) »

See 1 Publication for this product

Product Wall

The lysates that were used to validate the two P2RY5 antibodies for western blotting are not available for sale, but we at least have a lysate that is equivalent to the mouse heart lysate that was used in the blot shown on the ab113055 datasheet. The c...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"