p27 KIP 1肽(153-165) (ab45884)



  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 氨基酸153 to 165



Our Abpromise guarantee covers the use of ab45884 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-p27 KIP 1 antibody (ab45872)

  • 形式Liquid
  • Concentration information loading...


  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.


  • 别名
    • AA408329
    • AI843786
    • Cdki1b
    • CDKN 1B
    • CDKN 4
    • CDKN1B
    • CDKN4
    • Cyclin Dependent Kinase Inhibitor 1B
    • Cyclin dependent kinase inhibitor p27
    • Cyclin-dependent kinase inhibitor 1B
    • Cyclin-dependent kinase inhibitor 1B (p27, Kip1)
    • Cyclin-dependent kinase inhibitor p27
    • Cyclin-dependent kinase inhibitor p27 Kip1
    • KIP 1
    • KIP1
    • MEN1B
    • MEN4
    • OTTHUMP00000195098
    • OTTHUMP00000195099
    • p27
    • p27 Kip1
    • P27-like cyclin-dependent kinase inhibitor
    • p27Kip1
    see all
  • 功能Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
  • 组织特异性Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.
  • 疾病相关Defects in CDKN1B are the cause of multiple endocrine neoplasia type 4 (MEN4) [MIM:610755]. Multiple endocrine neoplasia (MEN) syndromes are inherited cancer syndromes of the thyroid. MEN4 is a MEN-like syndrome with a phenotypic overlap of both MEN1 and MEN2.
  • 序列相似性Belongs to the CDI family.
  • 结构域A peptide sequence containing only AA 28-79 retains substantial Kip1 cyclin A/CDK2 inhibitory activity.
  • 翻译后修饰Phosphorylated; phosphorylation occurs on serine, threonine and tyrosine residues. Phosphorylation on Ser-10 is the major site of phosphorylation in resting cells, takes place at the G(0)-G(1) phase and leads to protein stability. Phosphorylation on other sites is greatly enhanced by mitogens, growth factors, cMYC and in certain cancer cell lines. The phosphorylated form found in the cytoplasm is inactivate. Phosphorylation on Thr-198 is required for interaction with 14-3-3 proteins. Phosphorylation on Thr-187, by CDK2 leads to protein ubiquitination and proteasomal degradation. Tyrosine phosphorylation promotes this process. Phosphorylation by PKB/AKT1 can be suppressed by LY294002, an inhibitor of the catalytic subunit of PI3K. Phosphorylation on Tyr-88 and Tyr-89 has no effect on binding CDK2, but is required for binding CDK4. Dephosphorylated on tyrosine residues by G-CSF.
    Ubiquitinated; in the cytoplasm by the KPC complex (composed of RNF123/KPC1 and UBAC1/KPC2) and, in the nucleus, by SCF(SKP2). The latter requires prior phosphorylation on Thr-187. Ubiquitinated; by a TRIM21-containing SCF(SKP2)-like complex; leads to its degradation.
    Subject to degradation in the lysosome. Interaction with SNX6 promotes lysosomal degradation.
  • 细胞定位Nucleus. Cytoplasm. Endosome. Nuclear and cytoplasmic in quiescent cells. AKT-or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6 and this leads to lysosomal degradation.
  • Information by UniProt

p27 KIP 1 peptide (153-165) (ab45884)参考文献

ab45884 has not yet been referenced specifically in any publications.

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