概述

  • 产品名称Anti-p150 CAF1抗体
    参阅全部 p150 CAF1 一抗
  • 描述
    兔多克隆抗体to p150 CAF1
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Rhesus monkey, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region between residue 500 and 550 of Human p150 CAF1 (AAA76736.1).

  • 阳性对照
    • Human colon, colonic lymphoid aggregate and colon carcinoma tissue

性能

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应用

Our Abpromise guarantee covers the use of ab101286 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

靶标

  • 功能Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity). The CCR4-NOT complex functions as general transcription regulation complex. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.
  • 序列相似性Belongs to the CHAF1A family.
  • 发展阶段Active complex is found in G1, S and G2 phases.
  • 结构域Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus. DNA replication foci.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CAF 1 antibody
    • CAF 1 subunit A antibody
    • CAF antibody
    • CAF I 150 kDa subunit antibody
    • CAF I p150 antibody
    • CAF-1 subunit A antibody
    • CAF-I 150 kDa subunit antibody
    • CAF-I p150 antibody
    • CAF1 antibody
    • CAF1A_HUMAN antibody
    • CAF1B antibody
    • CAF1P150 antibody
    • CHAF1A antibody
    • Chromatin assembly factor 1 subunit A antibody
    • Chromatin Assembly Factor 1 Subunit A p150 antibody
    • Chromatin assembly factor I (150 kDa) antibody
    • Chromatin assembly factor I 150 kDa antibody
    • Chromatin assembly factor I p150 subunit antibody
    • DCAF1 antibody
    • hp150 antibody
    • MGC71229 antibody
    • P150 antibody
    see all

Anti-p150 CAF1 antibody 图像

  • ab101286, at 1/250 dilution, staining p150 CAF1 in a formalin-fixed paraffin-embedded section of Human colonic lymphoid aggregate by Immunohistochemistry using DAB staining.

Anti-p150 CAF1 antibody (ab101286)参考文献

ab101286 has not yet been referenced specifically in any publications.

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