概述

  • 产品名称Anti-p130抗体
  • 描述
    小鼠单克隆抗体to p130
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Orangutan
  • 免疫原

    Recombinant fragment: VTPVSTATHS LSRLHTMLTG LRNAPSEKLE QILRTCSRDP TQAIANRLKE MFEIYSQHFQ PDEDFSNCAK EIASKHFRFA EMLYYKVLES VIEQEQKRLG , corresponding to amino acids 416-516 of Human p130 with proprietary tag (NP_005602)

  • 阳性对照
    • 293 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab89459 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 128 kDa (predicted molecular weight: 128 kDa).
ELISA Use at an assay dependent dilution.

靶标

  • 相关性p130 is a key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
  • 细胞定位Nuclear
  • 数据库链接
  • 别名
    • 130 kDa retinoblastoma associated protein antibody
    • IB4 antibody
    • PPAR alpha interacting complex protein 128 antibody
    • PRB2 antibody
    • PRIC128 antibody
    • RB2 antibody
    • RBL2 antibody
    • Retinoblastoma like 2 antibody
    • retinoblastoma like 2 (p130) antibody
    • Retinoblastoma like protein 2 antibody
    • RETINOBLASTOMA RELATED GENE RB2 antibody
    see all

Anti-p130 antibody 图像

  • Anti-p130 antibody (ab89459) at 1 µg/ml + 293 cell lysate at 50 µg

    Predicted band size : 128 kDa
    Observed band size : 128 kDa
  • Detection limit for recombinant tagged ab89459 is approximately 1ng/ml as a capture antibody

Anti-p130 antibody (ab89459)参考文献

ab89459 has not yet been referenced specifically in any publications.

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