概述

  • 产品名称Anti-p107抗体
    参阅全部 p107 一抗
  • 描述
    兔多克隆抗体to p107
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Dog
  • 免疫原

    Synthetic peptidedesigned within residues: LDIFQNPYEE PPKLPRSRKQ RRIPCSVKDL FNFCWTLFVY TKGNFRMIGD, corresponding to amino acids 144 - 193 of Human p107 (NP_899662).

  • 阳性对照
    • COLO205 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab90507 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 121 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.
  • 序列相似性Belongs to the retinoblastoma protein (RB) family.
  • 翻译后修饰Exists in both phosphorylated and unphosphorylated forms, and T, but not E1A, binds only to the unphosphorylated form. Cell-cycle arrest properties are inactivated by phosphorylation on Thr-332, Ser-640, Ser-964 and Ser-975 by CDK4.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 107 kDa retinoblastoma-associated protein antibody
    • Cellular protein 107 antibody
    • Cellular protein p107 antibody
    • CP107 antibody
    • MGC40006 antibody
    • p107 antibody
    • PRB1 antibody
    • RBL1 antibody
    • RBL1_HUMAN antibody
    • Retinoblastoma like protein 1 antibody
    • retinoblastoma-like 1 (p107) antibody
    • Retinoblastoma-like protein 1 antibody
    see all

Anti-p107 antibody 图像

  • Anti-p107 antibody (ab90507) at 1 µg/ml + COLO205 cell lysate at 10 µg

    Secondary
    anti-Rabbit IgG HRP at 1/50000 dilution

    Predicted band size : 121 kDa

Anti-p107 antibody (ab90507)参考文献

ab90507 has not yet been referenced specifically in any publications.

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