PE Anti-P Glycoprotein抗体[UIC2] (ab93590)
Key features and details
- PE Mouse monoclonal [UIC2] to P Glycoprotein
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: PE. Ex: 488nm, Em: 575nm
- Isotype: IgG2a
概述
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产品名称
PE Anti-P Glycoprotein抗体[UIC2]
参阅全部 P Glycoprotein 一抗 -
描述
PE小鼠单克隆抗体[UIC2] to P Glycoprotein -
宿主
Mouse -
偶联物
PE. Ex: 488nm, Em: 575nm -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Human -
免疫原
Tissue, cells or virus corresponding to P Glycoprotein. Mouse Balb/c 3T3 fibroblasts transfected with Human P Glycoprotein cDNA
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阳性对照
- 8226 DOX40 and 8226/S cell lines
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常规说明
ab93590 has been reported to inhibit MDR1-mediated efflux.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.2
Preservative: 0.09% Sodium azide -
Concentration information loading...
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纯度
Protein G purified -
Primary antibody说明
ab93590 has been reported to inhibit MDR1-mediated efflux. -
克隆
单克隆 -
克隆编号
UIC2 -
同种型
IgG2a -
研究领域
相关产品
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Alternative Versions
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab93590于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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Flow Cyt |
Use 5µl for 106 cells.
Use 5 µl/test for 105-8 cells in 100µl.
ab91363 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
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说明 |
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Flow Cyt
Use 5µl for 106 cells. Use 5 µl/test for 105-8 cells in 100µl.
ab91363 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
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靶标
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功能
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. -
组织特异性
Expressed in liver, kidney, small intestine and brain. -
疾病相关
Genetic variations in ABCB1 are associated with susceptibility to inflammatory bowel disease type 13 (IBD13) [MIM:612244]. Inflammatory bowel disease is characterized by a chronic relapsing intestinal inflammation. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Crohn disease and ulcerative colitis are commonly classified as autoimmune diseases. -
序列相似性
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Contains 2 ABC transmembrane type-1 domains.
Contains 2 ABC transporter domains. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 5243 Human
- Omim: 171050 Human
- SwissProt: P08183 Human
- Unigene: 489033 Human
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别名
- ABC20 antibody
- ABCB1 antibody
- ATP binding cassette, sub family B (MDR/TAP), member 1 antibody
see all
图片
数据表及文件
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Datasheet download
文献 (10)
ab93590 被引用在 10 文献中.
- Cao Y et al. Surface plasmon resonance biosensor combined with lentiviral particle stabilization strategy for rapid and specific screening of P-Glycoprotein ligands. Anal Bioanal Chem 413:2021-2031 (2021). PubMed: 33528601
- Mendes LP et al. Surface-engineered polyethyleneimine-modified liposomes as novel carrier of siRNA and chemotherapeutics for combination treatment of drug-resistant cancers. Drug Deliv 26:443-458 (2019). PubMed: 30929529
- Guo HH et al. Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases. Nat Commun 10:1981 (2019). PubMed: 31040273
- Rafiee R et al. ABCB1 SNP predicts outcome in patients with acute myeloid leukemia treated with Gemtuzumab ozogamicin: a report from Children's Oncology Group AAML0531 Trial. Blood Cancer J 9:51 (2019). PubMed: 31113932
- Wang F et al. Hydroxychloroquine reverses the drug resistance of leukemic K562/ADM cells by inhibiting autophagy. Mol Med Rep 20:3883-3892 (2019). PubMed: 31485616
- Lopes A et al. Chiral Thioxanthones as Modulators of P-glycoprotein: Synthesis and Enantioselectivity Studies. Molecules 23:N/A (2018). PubMed: 29534440
- Wang CW et al. 7-ketocholesterol and 27-hydroxycholesterol decreased doxorubicin sensitivity in breast cancer cells: estrogenic activity and mTOR pathway. Oncotarget 8:66033-66050 (2017). PubMed: 29029490
- Huang XC et al. Parguerenes: Marine red alga bromoditerpenes as inhibitors of P-glycoprotein (ABCB1) in multidrug resistant human cancer cells. Biochem Pharmacol 85:1257-68 (2013). PubMed: 23415901
- Chaudhary PM et al. Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes. Blood 80:2735-9 (1992). PubMed: 1360267
- Mechetner EB & Roninson IB Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody. Proc Natl Acad Sci U S A 89:5824-8 (1992). PubMed: 1352877