Anti-P Glycoprotein抗体[JSB-1], prediluted (ab51893)

概述

  • 产品名称Anti-P Glycoprotein抗体[JSB-1], prediluted
    参阅全部 P Glycoprotein 一抗
  • 描述
    小鼠单克隆抗体[JSB-1] to P Glycoprotein, prediluted
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Chinese hamster ovary cell line (CHrC5) expressing Human MDR (170-180 kDa Glykoprotein)

  • 阳性对照
    • Human liver or renal carcinoma.

性能

应用

Our Abpromise guarantee covers the use of ab51893 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: we recommend using 100µl working solution per test and incubating the antibody for 60 mins at room temperature. Antigen unmasking required for paraffin embedded sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
    • 组织特异性Expressed in liver, kidney, small intestine and brain.
    • 疾病相关Genetic variations in ABCB1 are associated with susceptibility to inflammatory bowel disease type 13 (IBD13) [MIM:612244]. Inflammatory bowel disease is characterized by a chronic relapsing intestinal inflammation. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Crohn disease and ulcerative colitis are commonly classified as autoimmune diseases.
    • 序列相似性Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
      Contains 2 ABC transmembrane type-1 domains.
      Contains 2 ABC transporter domains.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ABC20 antibody
      • ABCB1 antibody
      • ATP binding cassette, sub family B (MDR/TAP), member 1 antibody
      • ATP-binding cassette sub-family B member 1 antibody
      • CD243 antibody
      • CLCS antibody
      • Colchicin sensitivity antibody
      • Doxorubicin resistance antibody
      • GP170 antibody
      • MDR1 antibody
      • MDR1_HUMAN antibody
      • Multidrug resistance 1 antibody
      • Multidrug resistance protein 1 antibody
      • P glycoprotein 1 antibody
      • P gp antibody
      • P-glycoprotein 1 antibody
      • PGY1 antibody
      see all

    Anti-P Glycoprotein antibody [JSB-1], prediluted (ab51893)参考文献

    ab51893 has not yet been referenced specifically in any publications.

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