概述

  • 产品名称Anti-P cadherin抗体
    参阅全部 P cadherin 一抗
  • 描述
    兔多克隆抗体to P cadherin
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A KLH conjugated synthetic peptide selected from the C-terminal region of human P cadherin.

  • 阳性对照
    • K562 and 293 cell lysates

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明This antibody was prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. Then the antibody was purified by peptide affinity purification.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

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应用

Our Abpromise guarantee covers the use of ab65599 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/50 - 1/100. Detects a band of approximately 91 kDa (predicted molecular weight: 91 kDa).
ELISA 1/1000.

靶标

  • 功能Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
  • 组织特异性Expressed in some normal epithelial tissues and in some carcinoma cell lines.
  • 疾病相关Defects in CDH3 are the cause of hypotrichosis with juvenile macular dystrophy (HJMD) [MIM:601553]. HJMD is a rare autosomal recessive disorder characterized by early hair loss heralding severe degenerative changes of the retinal macula and culminating in blindness during the second to third decade of life.
    Defects in CDH3 are the cause of ectodermal dysplasia with ectrodactyly and macular dystrophy (EEM) [MIM:225280]; also known as EEM syndrome, Albrectsen-Svendsen syndrome or Ohdo-Hirayama-Terawaki syndrome. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EEM is an autosomal recessive condition characterized by features of ectodermal dysplasia such as sparse eyebrows and scalp hair, and selective tooth agenesis associated with macular dystrophy and ectrodactyly.
  • 序列相似性Contains 5 cadherin domains.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CADH3_HUMAN antibody
    • Cadherin 3 antibody
    • Cadherin 3 precursor antibody
    • Cadherin 3 type 1 antibody
    • Cadherin-3 antibody
    • Cadp antibody
    • Calcium dependent adhesion protein placental antibody
    • CDH 3 antibody
    • CDH3 antibody
    • CDH3 protein antibody
    • CDHP antibody
    • HJMD antibody
    • P cadherin (placental) antibody
    • P-cadherin antibody
    • PCAD antibody
    • Placental cadherin antibody
    see all

Anti-P cadherin antibody 图像

  • Anti-P cadherin antibody (ab65599) at 1/60 dilution + K562 cell line lysates at 35 µg

    Predicted band size : 91 kDa
    Observed band size : 91 kDa
    Additional bands at : 46 kDa (possible non-specific binding).
  • All lanes : Anti-P cadherin antibody (ab65599) at 1/60 dilution

    Lane 1 : 293 cell line lysate nontransfected
    Lane 2 : 293 cell line lysate transiently transfected with the P cadherin gene

    Lysates/proteins at 2 µg/ml per lane.


    Predicted band size : 91 kDa
    Observed band size : 91 kDa
    Additional bands at : 46 kDa (possible non-specific binding).

Anti-P cadherin antibody (ab65599)参考文献

ab65599 has not yet been referenced specifically in any publications.

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