Oxaliplatin,Platinum anticancer agent (ab141054)
Key features and details
- Platinum anticancer agent. Induces DNA cross-linking.
- CAS Number: 61825-94-3
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Oxaliplatin,Platinum anticancer agent -
描述
Platinum anticancer agent. Induces DNA cross-linking. -
生物学描述
Diaminocyclohexane platinum anticancer agent. Induces DNA cross-linking and blocks DNA synthesis. Induces apoptosis and cell cycle arrest.
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纯度
> 99% -
CAS编号
61825-94-3 -
化学结构
性能
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化学名称
(SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN1,kN2][ethanedioato(2-)-kO1,kO2]-platinum -
分子量
397.29 -
分子式
C8H14N2O4Pt -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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来源
Synthetic
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研究领域
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (5)
ab141054 被引用在 5 文献中.
- Fernández Moro C et al. An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver. Nat Commun 14:5024 (2023). PubMed: 37596278
- Li D et al. Oxaliplatin induces the PARP1-mediated parthanatos in oral squamous cell carcinoma by increasing production of ROS. Aging (Albany NY) 13:4242-4257 (2021). PubMed: 33495407
- Tan Z et al. Environmental stresses induce karyotypic instability in colorectal cancer cells. Mol Biol Cell 30:42-55 (2019). PubMed: 30379607
- Yan S et al. PFKFB3 Inhibition Attenuates Oxaliplatin-Induced Autophagy and Enhances Its Cytotoxicity in Colon Cancer Cells. Int J Mol Sci 20:N/A (2019). PubMed: 31671668
- Vallecillo-Hernández J et al. Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs. Sci Rep 8:3593 (2018). PubMed: 29483523